| 摘要: |
| ［摘要］ 目的 研究鼻咽癌放射治疗中不同的照射剂量对CT与MRI颅底骨成像差异患者脑组织的影响。方法 对MRI与CT颅底骨成像差异病例26例，分别根据MRI与CT成像信息应用ARTP-TOP 3D-TPS系统制定三维适形计划，比较两计划脑组织平均剂量和D5平均剂量。结果 MRI计划中的脑干、垂体、左右颞叶和左右眼球的平均剂量（Gy）（47.01±4.61，59.59±8.80，5.92±3.72，6.55±3.80，38.27±6.15，38.78±7.52）计划大于CT计划中各个相应器官的平均剂量（Gy）（34.66±4.99，52.11±7.15，5.66±3.95，6.36±4.11，29.94±5.69，30.23±6.54）（P<0.05）有统计学意义；两个计划中脊髓平均剂量（Gy）（MRI 29.51±5.80，CT 30.30±4.04）比较无统计学意义；MRI计划中的脑干、脊髓、垂体、左右颞叶、左右眼球的D5平均剂量（Gy）（66.15±3.43，44.26±4.35，61.59±8.89，20.65±10.66，20.09±11.65，67.60±2.39，67.31±6.88）均大于CT计划中相应器官的D5平均剂量（Gy）（56.49±2.52，41.51±4.65，54.04±7.31，20.17±10.47，19.37±11.44，60.69±3.62，60.04±6.84）（P<0.05）。结论 根据MRI制定的三维适形计划，肿瘤靶区的剂量覆盖较CT好, 但是对脑组织的照射剂量相对CT的较高。 |
| 关键词: 鼻咽癌 放射治疗 CT MRI |
| DOI：10.3969/j.issn.1674-3806.2009.07.02 |
| 分类号:R 739.63 |
| 基金项目:广西医疗卫生重点科研课题基金项目（编号：200520） |
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| A simulation study on the impact of two different radiotherapy plans on radiation situation of the brain of patients with nasopharyngeal carcinoma with magnetic resonance imaging and computed tomography image difference in cranial base |
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QIN Ling, LI Ling, WANG An-yu
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The People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To study the impact of the treating dose of target volume in different radiotherapy plans on radiation situation of the brain of patients who suffer from nasopharyngeal carcinoma (NPC) with magnetic resonance imaging (MRI) and computed tomography（CT） image difference in cranial base.Methods According to the MRI and CT image difference in cranial base, we applied ARTP-TOP3D-TPS system to delineate target volume and develop the three-dimensional conformal radiotherapy (3-DCRT) plans. Tewenty-six NPC patients were treated by the 3-DCRT plans. The mean dose and D5 mean dose of the target volume in the two group(CT based plan and MRI based plan) were compared.Results Compared with CT based plan（34.66±4.99）Gy, （52.11±7.15）Gy, （5.66±3.95）Gy, （6.36±4.11）Gy, （29.94±5.69）Gy, （30.23±6.54）Gy, the mean dose of brainstem, pituitary, temporal lobe and both eyes in MRI based plan（47.01±4.61）Gy, （59.59±8.80）Gy, （5.92±3.72）Gy, （6.55±3.80）Gy, （38.27±6.15）Gy, （38.78±7.52）Gy were larger (P<0.05). There was no statistic difference in the mean dose of spinal cord between two plans［MRI （29.51±5.80）Gy, CT（30.30±4.04）Gy］. Compared with CT based plan（56.49±2.52）Gy, （41.51±4.65）Gy, （54.04±7.31）Gy, （20.17±10.47）Gy, （19.37±11.44）Gy, （60.69±3.62）Gy, （60.04±6.84）Gy, the D5 mean dose of brainstem, spinal cord, pituitary, temporal lobe and both eyes in MRI based plan（66.15±3.43）Gy, （44.26±4.35）Gy, （61.59±8.89）Gy, （20.65±10.66）Gy, （20.09±11.65）Gy, （67.60±2.39）Gy, （67.31±6.88）Gy were larger (P<0.05).Conclusion The dose of target volume in 3D-CRT plan based MRI is superior to CT. The dose of important organ of the brain in 3D-CRT plan based MRI is higher. |
| Key words: Nasopharyngeal carcinoma Radiotherapy, Computed tomography Magnetic resonance imaging |
