| 摘要: |
| ［摘要］ 目的 通过分析瘢痕疙瘩周围部和中央部组织中IGF-I、IGF-IR表达的差异，探讨瘢痕疙瘩呈浸润性生长的机制。方法 收集手术切除的瘢痕疙瘩组织8例及周围正常皮肤组织4例，对不同部位的瘢痕疙瘩组织和正常皮肤组织进行免疫组织化学染色，观察各组中IGF-I、IGF-IR的表达，比较瘢痕疙瘩不同部位和正常皮肤组织中IGF-I、IGF-IR表达的差异。结果 正常皮肤组织中成纤维细胞中IGF-I、IGF-IR的表达均呈阴性。瘢痕疙瘩周围组织成纤维细胞中IGF-I的表达明显高于中央部，差异有统计学意义(P<0.05)；瘢痕疙瘩周围部组织纤维细胞中IGF-IR明显高于中央部，差异有统计学意义(P<0.05)。 结论 瘢痕疙瘩不同部位IGF-I、IGF-IR的表达差异可能是导致瘢痕疙瘩呈浸润性生长的机制之一。 |
| 关键词: 瘢痕疙瘩 胰岛素样生长因子-I 胰岛素样生长因子-I受体 成纤维细胞 |
| DOI：10.3969/j.issn.1674-3806.2009.07.10 |
| 分类号:Q 753 |
| 基金项目: |
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| Expression and significance of IGF-I and IGF-IR in different part of keloid |
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HUNG Xin, SHAN Sheng-guo, WEI Hai-ming, et al.
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Department of Plastic Surgery, the People′s Hospital of Wuhan University, Wuhan 430060, China
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| Abstract: |
| ［Abstract］ Objective To explore the aggressive growth characteristics in peripheral parts and central parts of keloid by analysing the insulin-like growth factor-I (IGF-I) and the insulin-like growth factor-I receptor (IGF-IR) index.Methods Fibroblasts of 8 keloids cases and 4 normal skin cases were investigated by immunohistochemical analysis of IGF-I and IGF-IR. IGF-I and IGF-IR index of difference parts in keloids and normal skin were compared.Results These were no positive fibroblasts in normal skin samples. The IGF-I and IGF-IR index of peripheral parts of keloids are higher than those of central parts, and there is significant difference(P<0.05).Conclusion The difference in distribution of IGF-I and IGF-IR index may be responsible for the aggressive growth of keloid. |
| Key words: Keloid IGF-I IGF-IR Fibroblast |
