| 摘要: |
| ［摘要］ 目的 通过辛伐他汀对颈动脉粥样硬化斑块中的软斑块的干预，观察其能否有效干预颈动脉粥样硬化斑块中软斑块的进展，从而达到防治脑血管疾病（CVD）的目的。方法 将符合入选标准的300例患者随机分为治疗组和对照组，每组各150例。对照组采用氯吡格雷(75 mg/次，1次/d)， 治疗组在氯吡格雷治疗的基础上加辛伐他汀（三精制药厂生产，20 mg/次，每晚1次），疗程均为6个月。两组患者治疗6个月后复查彩超，记录斑块性质、大小和数目等。 结果 比较两组软斑块消退、软斑块数目减少、斑块稳定情况，治疗组显著优于对照组，差异有统计学意义(P<0.01)。结论 辛伐他汀能逆转和稳定动脉粥样硬化斑块，从而减少脑血管事件的发生。 |
| 关键词: 辛伐他汀 颈动脉粥样硬化 软斑块 |
| DOI：10.3969/j.issn.1674-3806.2009.07.20 |
| 分类号:R 541.4 |
| 基金项目: |
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| The effect of simvastatin on soft plaque of carotid atherosclerosis |
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ZHOU Te-fei, ZHANG Kui-hua, YIN Wei-qun
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Liangang Hospital, Loudi Hunan 417009, China
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| Abstract: |
| ［Abstract］ Objective To observe the effect of simvastatin on the soft plaque of carotid atherosclerosis.Methods Three hundred patients with carotid atherosclerosis were randomly divided into two groups and each group had 150 patients， respectively. The control group treated by clopidogrel(75mg qd) and the treatment group added simvastatin (20mg qn) besides clopidogrel. All patients rechecked by color doppler ultrasonography after 6 months′of treatment， then the variation of the carotid atherosclerosis in two group were compared.Results The soft plaque of carotid atherosclerosis in the treatment group had more incidence of extinction， decreasing or stabilization of soft plaque than control group.Conclusion Simvastatin can reverse and stabilize the belt plaque of carotid atherosclerosis. |
| Key words: Simvastatin Carotid atherosclerosis Soft plaque |
