| 摘要: |
| ［摘要］ 目的 探讨咪唑安定治疗小儿全身性惊厥性癫痫持续状态的临床疗效。方法 将72例小儿全身性惊厥性癫痫持续状态患者随机分为两组，治疗组38例给予静脉注射负荷量咪唑安定0.3 mg·kg-1后，用注射泵持续泵入咪唑安定，从2 μg·kg-1·min-1起, 每15 min增加1 μg·kg-1·min-1, 最大剂量10 μg·kg-1·min-1，至惊厥停止后，维持给药24 h。对照组给地西泮0.3 mg·kg-1静脉注射，最大剂量不超过10 mg, 惊厥未停止或又出现另一次惊厥发作者，15 min后再次注射同等剂量地西泮，同时使用苯巴比妥20 mg·kg-1静脉注射，12 h后按5 mg·kg-1肌注维持。结果 （1）治疗组惊厥完全控制35例，无效3例；对照组惊厥完全控制25例，无效9例，两者之间差异有统计学显著意义（P﹤0.05）；（2）治疗组停药后患儿完全恢复清醒状态时间平均（8.2±4.1）h，对照组平均（14.3±6.7）h，两者比较差异有统计学极显著意义（P<0.01）；（3）治疗组惊厥控制时间平均为（38±23）min，对照组平均为（48±29）min，两者比较差异有统计学显著意义（P<0.05）；(4)静注负荷量咪唑安定仅出现一过性心率和血压下降。结论 咪唑安定治疗小儿全身性惊厥性癫痫持续状态疗效肯定。 |
| 关键词: 咪唑安定 惊厥性癫痫持续状态 治疗 小儿 |
| DOI：10.3969/j.issn.1674-3806.2009.10.24 |
| 分类号:R 742.1 |
| 基金项目: |
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| Clinical observation on effect of midazolam in treatment of convulsive status epilepticus in children |
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SU Ping, CHEN Bei, CAI Xia
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Department of Pediatrics, Sixth Affiliated Hospital, Guangxi Madical University, Yulin Guangxi 537000, China
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| Abstract: |
| ［Abstract］ Objective To investigate the effect of midazolam in treatment of convulsive status epilepticus(CSE) in children.Methods Seventy-two cases of children with CSE were randomly divided into two groups: Treatment group (38 cases) were treated by intravenous infusion of midazolam 0.3 mg·kg-1 first, and then given continuous intravenous infusion of midazolam by the injection pump, the initial dose was 2μg·kg-1·min-1, and increasing 1 μg·kg-1·min-1 for every 15 minutes, the maximum dose reached 10 μg·kg-1·min-1, after the convulsions stopped, the drug continue maintained for 24 hours. Control group treated by intravenous injection of diazepam 0.3 mg·kg-1, the maximum dose was not exceeding 10 mg, if the convulsions did not stopped or occurred another convulsion, re-injected the same dose of diazepam after 15 minutes, and treated by intravenous injection of phenobarbital 20 mg·kg-1 in the same time, the maintainous dose of 5 mg·kg-1 was given by intramuscular injection 12 hours later.Results （1）There were 35 cases whose convulsions were completely controlled, and 3 cases were invalid in treatment group; And there were 25 cases whose convulsions were completely controlled, and 9 cases were invalid in control group(P<0.05); （2）It took (8.2 ± 4.1)h for treatment group to fully recover, and (14.3 ± 6.7)h for control group(P<0.01); （3）It took (38 ± 23) minutes for treatment group to control CSE, and (48 ± 29) minutes for control group(P<0.05); （4）Intravenous injected loading dose of midazolam only caused transient heart rate and blood pressure drop.Conclusion The effect of midazolam in treatment of CSE in children was positive. |
| Key words: Midazolam Convulsive status epilepticus Treatment Pediatrics |
