| 摘要: |
| ［摘要］ 免疫器官是免疫细胞再生、分化的重要场所，淋巴结（lymph nodes，LNs）作为外周免疫器官，其正常结构对于维持自身内环境稳定和免疫细胞的生存、发育、增生是非常重要的。近来，国外有研究发现胶原纤维在淋巴组织中T细胞区域（T cell zone，TZ）的沉积可能是导致HIV感染者外周血和淋巴组织中CD4+ T细胞减少的又一重要机制。该文拟根据近年研究进展，阐述LNs正常组织结构对CD4+ T细胞存活、发育和运输的影响及其结构改变与获得性免疫缺陷综合征（AIDS）发病机制的关系，以期对目前AIDS发病机制和临床治疗的研究有所裨益。 |
| 关键词: 淋巴结 获得性免疫缺陷综合征 人类免疫缺陷病毒 |
| DOI：10.3969/j.issn.1674-3806.2010.06.40 |
| 分类号:R 512.91 |
| 基金项目: |
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| The structure of lymph nodes and the relationship between its changed structure and the pathogenesis of acquired immune deficiency syndrome |
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LU Xiang-chan,TAN Yi
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Department of Infection, Nanning Fourth People′s Hospital, Guangxi 530023, China
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| Abstract: |
| ［Abstract］ The immune organs are important zones for immune cells to regenerate and differentiate. The normal structure of lymph nodes (LNs) as peripheral immune organs is crucial to keeping own inner environment balance and keeping the immune cells surviving, growing and regenerating. Recently, some foreign researchers find that the accumulation of collagen fibers in T cell zone (TZ) may be another important pathogenesis of decreasing CD4+ T cells in peripheral blood and lymph tissues in HIV infectors. This paper expounds the effect of normal LNs structure on CD4+ T cells′ surviving, growing and transporting, and explains the relationship between changed structure and pathogenesis of acquired immune deficiency syndrome(AIDS), so that it would be helpful in the study of present pathogenesis and clinical treatment of AIDS. |
| Key words: Lymph nodes (LNs) Acquired immune deficiency syndrome (AIDS) Human immunodeficiency virus (HIV) |
