| 摘要: |
| ［摘要］ 目的 探讨拉西地平（司乐平）对广西轻中度原发性高血压的降压疗效。方法 选50例轻中度原发性高血压患者采用自身对照开放法，停用原来降压药物2周后随诊血压（CBP）仍≥160/95 mmHg（1 mmHg=0.133 kPa）者口服拉西地平4～8 mg/d共4周，期间不服用其他降压药。结果 治疗4周后随诊血压(CBP）降低总有效率为88%，动态血压曲线明显降低，谷峰比值收缩压为65.2%，舒张压为61.1%。结论 国产拉西地平4～8 mg/d对轻中度原发性高血压患者具有安全有效的降压作用，耐受性好，不良反应少。 |
| 关键词: 高血压病 拉西地平 24 h动态血压 |
| DOI：10.3969/j.issn.1674-3806.2011.09.10 |
| 分类号:R 544.1 |
| 基金项目: |
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| The effect of domestic lacidipine on 24-hour ambulatory blood pressure in 50 patients with essential hypertention |
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LU Zhi-hong
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Department of Cardiology,the People′s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China
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| Abstract: |
| ［Abstract］ Objective To explore the therapeutic effect of lacidipine in the treatment of patients with mild to moderate hypertention. Methods By the open self-control method, 50 patients with casual blood pressure(CBP) ≥160/95 mmHg affter 2 weeks of stopping antihypertensive drugs, received lacidipine 4～8 mg daily for 4 weeks without any other antihypertensive drugs. The 24 h ambulatory blood pressure monitoring (ABPm) and CBP were obsered. Results After 4 weeks of treatment CBP reduced, the total effective rate was 88%, the curve of ABPm descended after treatment, the trough-peak ratio of systolic blood pressure was 65.2%, the trough-peak ratio of diastolic blood pressure was 61.1%. Conclusion Doses of 4～8 mg/d domestic lacidipine have a safe and effective effect in the treatment of patients with mild to moderate hypertention with better tolerance and less adverse reactions. Lacidiple is a safe and effective antihypertensive drug. |
| Key words: Hypertension Lacidipine 24 h ambulatory blood pressure |
