| 摘要: |
| ［摘要］ 目的 探讨儿童噬血细胞综合征的临床特点。方法 回顾性分析26例感染相关性噬血细胞综合征病的临床及实验室资料。结果 感染相关性17例(65.38%),非感染相关性3例(11.54%)，原因不明6例（23.08%）。全组病例临床主要特点为持续高热(100.0%)、肝肿大(84.62%)、脾肿大(92.31%);外周血白细胞计数减少(76.92%)、血小板减少(88.46%)、血红蛋白减少(80.77%)；骨髓涂片找到噬血细胞(100.0%)。结论 儿童感染相关性噬血细胞综合征临床以持续高热、肝肿脾大为主要表现,实验室检查白细胞计数、血红蛋白及血小板中两系或三系减少、低纤维蛋白血症、高脂血症、肝功能、心功能异常及血清铁蛋白升高,骨髓找到噬血细胞等为主要特点。 |
| 关键词: 嗜血细胞综合征 儿童 诊断 |
| DOI：10.3969/j.issn.1674-3806.2012.01.06 |
| 分类号:R 725.5 |
| 基金项目: |
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| Analysis of laboratory examination in 26 children with hemophagocytic syndrome |
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ZHANG Hui, MO Wu-ning, LI Ping
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Department of Clinical Laboratory, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To investigate the clinical features of children with hemophagocytic syndrome (HPS).Methods The clinical and laboratory data of 26 cases with infection-associated HPS were analyzed retrospectively.Results In all the 26 cases of HPS, 17 cases were infection-associated（65.38%), 3 cases were not infection-associated (11.54%), 6 cases were unknown causes (23.08%).The main clinical characteristics of the disease in this group were sustaining fever (100.00%), hepatomegaly (84.62%), splenomegaly (92.31%). Laboratory tests showed decrease of peripheral white blood count (76.92%), of blood platelet (88.46%), of hemoglobin (80.77%), hemophagocytes in bone marrow slides (100.00%).Conclusion The main manifestations of HPS are continuing hyperpyrexia, hepatomegaly and splenomegaly ; the laboratory findings include decrease of white blood count, hemoglobin or blood platelet, hypertriglyceridemia, liver disfunction, elevation of serum ferritin, and the hemophagocytes in bone marrow. |
| Key words: Hemophagocytic syndrome Child Diagnosis |
