| 摘要: |
| ［摘要］ 目的 探讨急性病毒性脑炎(AVE)患者的临床特点与病原学的关系。方法 回顾性分析220例确诊为AVE住院患者［随访时间最短150 d,最长18月，失访13例（5.9%）；≤14岁179例（81.36%），≥15岁41例（18.64%）］的临床资料。结果 220例患者血液和脑脊液（CSF）均检测出相关病毒特异性抗体IgM阳性。依次为单纯疱疹病毒-1（HSV-1）146例（66.36%），腮腺炎病毒（PXV）21例（9.55%），柯萨奇病毒-A/B（CSV-A/B）19例（8.64%），带状疱疹病毒（VZV）12例（5.45%），巨细胞病毒（CMV）10例（4.55%），乙型脑炎病毒（JEV）7例（3.18%），EB病毒5例（2.27%）。临床治疗总有效率为90.46%，病死率为9.55%。结论 血清和CSF检测有助于明确AVE病原学，及时早期应用有效抗病毒药物，可明显改善AVE预后。 |
| 关键词: 急性脑炎 病毒性 病原学 预后 |
| DOI：10.3969/j.issn.1674-3806.2012.04.11 |
| 分类号:R 373.3+1 |
| 基金项目: |
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| Analysis on clinical features and etiology of acute viral encephalitis:Report of 220 cases |
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LUO Yong-jian,LI Lv-li,LIN Xin-jing,et al.
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Department of Neurology,the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021,China
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| Abstract: |
| ［Abstract］ Objective To explore the correlation between clinical features and etiology in the patients with acute viral encephalitis (AVE).Methods Two hundred and twenty patients with AVE treated in our hospital from January 1991 to December 2005 were retrospectively analyzed.Results The shortest follow-up time was 150 days and the longest was 18 months. Thirteen patients failed to be followed up, the lost rate was 5.9% among 220 patients.One hundred and seventy-nine patients in the ≤14 age group; 41 patients in the ≥15 age group. In the blood and CSF of 220 patients AVE associated specific antibodies IgM were detected. The results showed HSV-1 positive in 146 patients, PXV positive in 21 patients, CSV-A/B positive in 19 patients, VZV positive in 12 patients, CMV positive in 10 patients, JEV positive in 7 patients and EB positive in 5 patients. The total effective rate was 90.46%,the mortality rate was 9.55%.Their prognosis were good after being treated in time.Conclusion Detection of serum and CSF are helpful in diagnosis of the etiology of AVE.And early use of effective antiviral drugs significantly improve the prognosis. |
| Key words: Acute viral encephalitis Etiology Prognosis |
