| 摘要: |
| ［摘要］ 目的 探讨Bmi-1在非小细胞肺癌(NSCLC)组织中的表达及其与临床病理特征关系,并研究其与p16表达的相关性。方法 采用免疫组化法检测NSCLC癌组织及正常肺组织中Bmi-1和p16的表达情况。结果 NSCLC组织中Bmi-1阳性表达率明显高于正常肺组织；Bmi-1与肿瘤癌组织的TNM分期及有无淋巴结转移呈正相关。NSCLC组织中Bmi-1和p16表达呈负相关(r=-0.281,P<0.05)。结论 Bmi-1在NSCLC发生发展及转移中发挥着重要作用。 |
| 关键词: Bmi-1 p16 非小细胞肺癌 |
| DOI：10.3969/j.issn.1674-3806.2013.04.15 |
| 分类号:R 734.2 |
| 基金项目: |
|
| The expression of Bmi-1 in non-small cell lung carcinoma and its relationship with the expression of p16 |
|
ZHAO Jun-sheng, CHEN Xiao-yan
|
|
Department of Pathology, the People’s Hospital of Jiaonan City, Shandong 266400, China
|
| Abstract: |
| ［Abstract］ Objective To investigate the expression and significance of Bmi-1 in non-small cell lung carcinoma(NSCLC) tissue, and evaluate its relationship with the expression of p16.Methods The quantities of Bmi-1 and p16 protein expression were detected by immunohistochemical assay in NSCLC and normal lung tissues.Results Immunohistochemical studies showed that the positive rate of Bmi-1 in NSCLC tissues was significantly higher than that in normal lung tissues, and the expression of Bmi-1 significantly associated with TNM staging and lymph node metastasis. The expression of Bmi-1 was significant negatively associated with the expression of p16 in NSCLC tissues (r=-0.281, P<0.05).Conclusion It has shown that Bmi-1 has important effect in the progression and metastasis of NSCLC. |
| Key words: Bmi-1 p16 Non-small cell lung carcinoma(NSCLC) |
