| 摘要: |
| ［摘要］ 目的 观察右美托咪定对不同年龄患者顺行性遗忘作用的影响。方法 选择美国麻醉医师学会（ASA）Ⅰ～Ⅱ级、年龄18～84岁，在腰硬联合麻醉下复合右美托咪定行下腹部（剖宫产术除外）手术患者120例，其中男73例，女47例。根据患者年龄的不同分为四组：A组(23±4)岁，B组（36±3）岁，C组（65±3）岁，D组（75±5）岁。所有患者均给予右美托咪定负荷量1 μg/kg，泵入10 min之后以0.2 μg·kg-1·h-1剂量维持。术后24 h回访患者并评定右美托咪定的顺行性遗忘作用。结果 A组和B组右美托咪定顺行性遗忘作用无明显不同（P>0.05），而C组与D组较前两组右美托咪定顺行性遗忘作用比较明显（P<0.05），并随年龄的增大明显增加（P<0.05）。结论 右美托咪定具有一定的顺行性遗忘作用，且对老年患者更为明显。 |
| 关键词: 右美托咪定 顺行性遗忘 腰硬联合麻醉 年龄 |
| DOI：10.3969/j.issn.1674-3806.2015.08.06 |
| 分类号:R 971+.2 |
| 基金项目: |
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| Effects of dexmedetomidine on the anterograde amnesia in patients with different ages |
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HU Zhi-chao, KONG Li, XU Peng-cheng, et al.
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Department of Anesthesiology, the First People′s Hospital of Shangqiu City, Henan 476100, China
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| Abstract: |
| ［Abstract］ Objective To study the effects of dexmedetomidine on the anterograde amnesia in patients with different ages.Methods One hundred and twenty ASAⅠ～Ⅱ patients, age from 18 years to 84 years, 73 cases of male and 47 cases of female, who were dministered spinal-epidural anesthesia combined with dexmedetomidine and performed operation on hypogastrium(except for caesarean section). All patients were randomly divided into four groups: group A, group B, group C and group D. Dexmedetomidine(1 μg/kg) was infused intravenously for 10 min and the maintenance dose was 0.2 μg·kg-1·h-1. The anterograde amnesia degree of dexmedetomidine was assessed 24 h after the operation.Results There was no significant difference in the anterograde amnesia of dexmedetomidine between group A and group B（P>0.05），while there were significant differences in group C and group D compared with both group A and group B（P<0.05）.Conclusion Anterograde amnesia occurs after using dexmedetomidine in elderly patients and with aging, the anterograde amnesia becomes more severe. |
| Key words: Dexmedetomidine Anterograde amnesia Spinal-epidural anesthesia Age |
