| 摘要: |
| ［摘要］ 目的 分析2012～2014年青岛市百日咳综合征发病趋势及治疗体会。方法 对2012-01～2014-12青岛市妇女儿童医院呼吸科住院病房收治的82例百日咳综合征患儿的病例资料进行回顾性分析。结果 （1）2012年组、2013年组、2014年组三组患儿发病均有明显的年龄特点及季节性，发病年龄在2个月～1岁10个月之间，其中以<6个月为主。男37例（45.12%），女45例（54.88%）。春夏季70例（85.37%），秋冬季12例（14.63%）。城市29例（35.37%），农村53例（64.63%）。（2）2014年组患儿病原学检出更多元化，混合感染增多，病原学检出肺炎支原体11例，腺病毒5例，鲍曼不动杆菌1例，阴沟肠杆菌3例等，未检出病原6例。单一病原感染40例，2种病原感染7例，3种病原感染3例。三组患儿均未检出百日咳杆菌。（3）2014年组患儿影像学表现更复杂，支气管肺炎、间质改变、肺不张、胃食管反流增多。（4）2014年组较2012年组及2013年组合并球结膜出血、喘息患者增多，治疗困难增大，抗生素联合应用增多，平均住院日增加，差异有统计学意义（P<0.05）。结论 百日咳综合征发病具有明显季节性，以春夏为多，发病趋势逐年上升，病原学复杂，合并症复杂，治疗难度增大，抗生素联合应用增多，平均住院日增加。百日咳综合征与百日咳临床特点相似，亟需高灵敏度和高特异度的百日咳杆菌实验室诊断方法应用于临床,针对病因正确评估规范处理是治疗成功的关键。 |
| 关键词: 百日咳综合征 病因 发病趋势 |
| DOI：10.3969/j.issn.1674-3806.2016.07.11 |
| 分类号:R 56 |
| 基金项目: |
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| The clinical analysis of pertussis syndrome in Qingdao city from 2012 to 2014 |
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WANG Li-yan, WANG Wen-di, FAN Wen-wen, et al.
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Department of Respiratory, Women and Children′s Hospital of Qingdao, Shandong 266000, China
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| Abstract: |
| ［Abstract］ Objective To analyze the incidence trend and treatment of pertussis syndrome in Qingdao city from 2012 to 2014.Methods A retrospective study was performed on 82 infants with pertussis syndrome who was hospitalized in the department of respiratory in Women and Children′s Hospital of Qingdao from January 2012 to December 2014.Results (1)Pertussis syndrome was characterizd by age, season and residence. The age ranged from 2 months to 22 months, and the most patients were younger than 6 months. The total 82 patients were constituted by 37 males(45.12%) and 45 females(54.88%). Of the 82 patients, 70 cases(85.37%) were hospitalized in spring and summer, and the rest of 12 cases(14.63%) were hospitalized in autumn and winter, 29 cases(35.37%) came from city area, the other 53 cases(64.63%) from rural places. (2)More diverse etiologies were fund in the patients in 2014. Of the 82 patients, 11 cases were infected by mycoplasma pneumoniae, 5 cases by adenovirus, 1 case by baumanii, 3 cases by enterobacter cloacae and 6 cases uninfected. Single pathogen infection was found in 40 cases. Infections by two kinds of pathogens were found in 7 cases, and three kinds of pathogens were found in 3 cases. Bordetella pertussis couldn′t be found in all cases. (3)The imaging findings were more complicated in patients in 2014. Bronchial pneumonia, interstitial change, atelectasis and gastroesophageal reflux were more common in 2014 than in 2012 and 2013. (4)More complicated conjunctival hemorrhage and wheeze were found in the patients in 2014 and they need a combination of many kinds of antibiotics and their average hospital stay was longer.Conclusion Pertussis syndrome has obvious seasonal characters to occur, and the incidence trend is increased year by year. The etiology and complications are more complicated, which leads to a difficult treatment and a combination of antibiotics. |
| Key words: Pertussis syndrome Etiology Incidence trend |
