| 摘要: |
| ［摘要］ 鼻咽癌是起源于鼻咽上皮的恶性肿瘤，且鼻咽癌微环境是影响其生长与转移的关键因素。微环境中外泌体携带的大量功能性蛋白质、mRNA、miRNA、DNA片段等多种生物活性物质，可以通过不同的作用机制调控肿瘤细胞的迁移、侵袭及血管的形成，还可以影响肿瘤的缺氧环境。因此，探究微环境中重要的外泌体和其信号通路机制，对了解鼻咽癌的治疗及预后评估有重要价值。该文就鼻咽癌微环境的相关外泌体及其通过不同作用方式调控肿瘤作用机制的研究进展作一综述。 |
| 关键词: 鼻咽癌 微环境 外泌体 调控机制 |
| DOI：10.3969/j.issn.1674-3806.2021.10.22 |
| 分类号:R 73 |
| 基金项目:国家自然科学基金项目（编号：81260348） |
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| Research progress on the mechanisms of exosomes in microenvironment of nasopharyngeal carcinoma |
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ZHONG Yu-xiao, HAO Yan-rong
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Department of Oncology, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Nasopharyngeal carcinoma is a malignant tumor originating from nasopharyngeal epithelium, and the microenvironment of nasopharyngeal carcinoma is the key factor affecting its growth and metastasis. A large number of functional proteins, mRNA, miRNA, DNA fragments and other bioactive substances carried by exosomes in the microenvironment can regulate the migration, invasion and angiogenesis of tumor cells through different mechanisms of action, and can also affect the hypoxic environment of tumors. Therefore, exploring the important exosomes and their signaling pathway mechanisms in microenvironment is of great value to understand the treatment and prognosis evaluation of nasopharyngeal carcinoma. This paper reviews the related exosomes of nasopharyngeal carcinoma microenvironment and research progress of their mechanisms in regulating tumors through different modes of action. |
| Key words: Nasopharyngeal carcinoma Microenvironment Exosomes Regulatory mechanism |
