| 摘要: |
| ［摘要］ 目的 探讨超声造影(CEUS)检查联合粪便钙卫蛋白（FC）检测评估克罗恩病（CD）活动性的应用价值。方法 回顾性分析2021年1月至2023年6月香港大学深圳医院收治的45例CD患者的临床资料，根据克罗恩病活动指数(CDAI)评分其分为缓解期组（<150分，18例）和活动期组（150～450分，27例）。所有患者行常规肠道超声检查及CEUS，采用双抗体夹心法检测FC水平。采用受试者工作特征（ROC）曲线分析CEUS指标峰值强度（PI）、曲线下面积（AUC）及FC水平评估CD活动性的效能。结果 缓解期组PI、AUC指标及FC水平均低于活动期组，差异有统计学意义（P<0.05）。Pearson相关性分析结果显示，CDAI评分与PI（r=0.506，P<0.001）、AUC（r=0.544，P<0.001）指标及FC（r=0.364，P=0.014）水平均呈正相关。ROC曲线分析结果显示PI、AUC指标及FC水平均具有评估CD活动性的应用价值（P<0.05），且三指标联合的评估效能进一步提高［AUC(95%CI)=0.908(0.815～1.000)，P<0.001］，灵敏度和特异度分别达96.30%、83.33%。结论 CEUS检查联合FC检测能有效评估CD活动性，有助于临床医师判断患者病情，及时调整合适的治疗方案。 |
| 关键词: 克罗恩病 粪便钙卫蛋白 肠道超声 超声造影 |
| DOI：10.3969/j.issn.1674-3806.2023.12.06 |
| 分类号:R 574 |
| 基金项目: |
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| A study on the application value of contrast-enhanced ultrasonography combined with fecal calprotectin detection in assessing the activity of Crohn′s disease |
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CHEN Jing, DONG Zhen-yu, YANG Dong-ye, et al.
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Department of Ultrasound, the University of Hong Kong-Shenzhen Hospital, Guangdong 518025, China
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| Abstract: |
| ［Abstract］ Objective To investigate the application value of contrast-enhanced ultrasonography(CEUS) combined with fecal calprotectin(FC) detection in assessing the activity of Crohn′s disease(CD). Methods The clinical data of 45 CD patients who were admitted to the University of Hong Kong-Shenzhen Hospital from January 2021 to June 2023 were retrospectively analyzed. According to CD activity index(CDAI) scores, the patients were divided into remission group(<150 points, 18 cases) and active stage group(150-450 points, 27 cases). All the patients underwent routine intestinal ultrasonography and CEUS, and FC levels were detected by double antibody sandwich method. Peak intensity(PI), area under the curve(AUC) and FC level of the CEUS indicators were analyzed using receiver operating characteristic(ROC) curve to assess the activity of CD. Results The indicators of PI and AUC, and the FC level in the remission group were lower than those in the active stage group, and the differences were statistically significant(P<0.05). The results of Pearson correlation analysis showed that CDAI score was positively correlated with the indicators of PI(r=0.506, P<0.001) and AUC(r=0.544, P<0.001), and the FC(r=0.364, P=0.014) level. The results of ROC curve analysis showed that the indicators of PI and AUC, and the FC level all had application value in assessing the activity of CD(P<0.05), and the combined assessing efficacy of the three indicators was further improved［AUC(95%CI)=0.908(0.815-1.000), P<0.001］, and the sensitivity and the specificity were 96.30% and 83.33%, respectively. Conclusion CEUS combined with FC detection can effectively assess the activity of CD, which helps clinicians judge the patients′ conditions and timely adjust the appropriate treatment plans. |
| Key words: Crohn′s disease(CD) Fecal calprotectin(FC) Intestinal ultrasound Contrast-enhanced ultrasonography(CEUS) |
