| 摘要: |
| ［摘要］ 目的 探讨温针灸联合富血小板血浆（PRP）宫腔灌注对肾虚血瘀型薄型子宫内膜患者冻融胚胎移植结局的影响。方法 招募2020年1月至2022年12月于钦州市妇幼保健院生殖医学中心行体外受精-胚胎移植(IVF-ET)的肾虚血瘀型薄型子宫内膜患者154例，根据患者治疗意愿将其分为A组（27例，接受激素替代周期）、B组（43例，接受激素替代周期+温针灸治疗）、C组（48例，接受激素替代周期+宫腔灌注PRP治疗）和D组（36例，接受激素替代周期+温针灸+宫腔灌注PRP治疗）。在给予孕酮转化子宫内膜后第3天移植1～2个优质卵裂期胚胎。比较四组转化日子宫内膜厚度、临床妊娠率、生化妊娠率、早期流产率。结果 经治疗后，B组、C组和D组的转化日子宫内膜厚度均较前一周期有所增长，差异有统计学意义（P<0.05），且B组、C组和D组的转化日子宫内膜厚度均显著大于A组（P<0.05），但B组、C组、D组间比较差异无统计学意义（P>0.05）。四组移植胚胎数比较差异无统计学意义（P>0.05）。四组临床妊娠率和生化妊娠率比较差异有统计学意义（P<0.05），以D组临床妊娠率和生化妊娠率最高，分别达44.44%和61.11%。四组早期流产率比较差异无统计学意义（P>0.05）。结论 温针灸联合PRP宫腔灌注有助于改善肾虚血瘀型薄型子宫内膜患者的子宫内膜厚度及冻融胚胎移植结局。 |
| 关键词: 富血小板血浆 温针灸 冻融胚胎移植 薄型子宫内膜 肾虚血瘀型 妊娠结局 |
| DOI：10.3969/j.issn.1674-3806.2024.09.15 |
| 分类号:R 711.6 |
| 基金项目:广西中医药管理局自筹项目（编号：GXZYN20220576） |
|
| Effect of warming acupuncture combined with intrauterine perfusion of platelet-rich plasma on the outcome of freeze-thaw embryo transfer in patients with thin endometrium of kidney deficiency and blood stasis type |
|
LIN Chunlian, LIU Yanmei, ZHANG Zhao, WU Hongbo
|
|
Reproductive Medicine Center, Qinzhou Maternal and Child Health Hospital, Guangxi 535000, China
|
| Abstract: |
| ［Abstract］ Objective To explore the effect of warming acupuncture combined with intrauterine perfusion of platelet-rich plasma(PRP) on the outcome of freeze-thaw embryo transfer in patients with thin endometrium of kidney deficiency and blood stasis type. Methods One hundred and fifty-four patients with thin endometrium of kidney deficiency and blood stasis type who underwent in vitro fertilization and embryo transfer(IVF-ET) in the Reproductive Medicine Center of Qinzhou Maternal and Child Health Hospital from January 2020 to December 2022 were recruited. According to the patients′ treatment intentions, they were divided into group A(27 cases, receiving hormone replacement cycle), group B(43 cases, receiving hormone replacement cycle+warming acupuncture treatment), group C(48 cases, receiving hormone replacement cycle+intrauterine perfusion of PRP treatment) and group D(36 cases, receiving hormone replacement cycle+warming acupuncture+intrauterine perfusion of PRP treatment). On the third day after administering progesterone to transform the endometrium, 1 to 2 high-quality cleavage stage embryos were transplanted. The endometrial thickness on the day when progesterone was administered to transform the endometrium, clinical pregnancy rate, biochemical pregnancy rate and early abortion rate were compared among the four groups. Results After treatment, the endometrial thickness in group B, group C and group D on the day when progesterone was administered to transform the endometrium increased compared with those in the previous cycle, and the differences were statistically significant(P<0.05), and the endometrial thickness in group B, group C and group D on the day when progesterone was administered to transform the endometrium was significantly greater than that in group A(P<0.05). However, there was no statistically significant difference among group B, group C and group D(P>0.05). There was no statistically significant difference in the number of transplanted embryos among the four groups. There were statistically significant differences in the clinical pregnancy rate and biochemical pregnancy rate among the four groups(P<0.05), and the clinical pregnancy rate and biochemical pregnancy rate in group D were the highest, which were 44.44% and 61.11%, respectively. There was no significant difference in the early abortion rate among the four groups(P>0.05). Conclusion Warming acupuncture combined with intrauterine perfusion of PRP helps to improve the endometrial thickness and the outcome of freeze-thaw embryo transfer in patients with thin endometrium of kidney deficiency and blood stasis type. |
| Key words: Platelet-rich plasma(PRP) Warming acupuncture Freeze-thaw embryo transfer Thin endometrium Kidney deficiency and blood stasis type Pregnancy outcome |
