| 摘要: |
| ［摘要］ 目的 探讨B7-H3在小细胞肺癌（SCLC）中的表达水平及其与患者预后的关联性。方法 收集2010年1月至2019年7月于首都医科大学附属北京胸科医院经外科手术切除的SCLC组织标本34份，并收集标本来源患者的病历资料和随访资料。采用免疫组化方法检测SCLC组织B7-H3的表达情况，并分析其表达水平与患者临床特征的关联性。结果 B7-H3高表达14例（41.18%），B7-H3低表达20例（58.82%）。B7-H3表达阳性26例（76.47%），表达阴性8例（23.53%）。B7-H3高表达组淋巴结转移比例及淋巴结转移数目高于B7-H3低表达组，差异有统计学意义（P<0.05），两组性别、年龄、吸烟比例比较差异无统计学意义（P>0.05）。B7-H3表达与微血管密度（MVD）评分之间存在一致性（Kappa=0.339，P=0.048）。B7-H3高表达组MVD评分高于B7-H3低表达组，差异有统计学意义（t=3.784，P=0.001）。B7-H3高表达组的中位总生存期短于B7-H3低表达组（13.8个月 vs 23.5个月），两组生存预后比较差异有统计学意义（log-rank检验： χ2=3.873，P=0.049）。结论 B7-H3在SCLC组织中有不同程度表达，B7-H3高表达与淋巴结转移、不良预后相关，有可能成为SCLC治疗的潜在靶标。 |
| 关键词: 小细胞肺癌 B7-H3 预后 |
| DOI：10.3969/j.issn.1674-3806.2024.12.07 |
| 分类号:R 734.2 |
| 基金项目: |
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| A study on B7-H3 expression in small-cell lung cancer and its correlation with the small-cell lung cancer patients′ prognosis |
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LI Xi1, LI Hongxia1, LIN Haifeng2, WANG Shouzheng1, ZHANG Quan1, LYU Jialin1, LI Jie1, ZHENG Hua1, HU Ying1
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1.Department of Medical Oncology, Beijing Chest Hospital, Capital Medical University(Beijing Tuberculosis and Thoracic Tumor Research Institute), Beijing 101149, China; 2.Department of Pathology, Beijing Chest Hospital, Capital Medical University(Beijing Tuberculosis and Thoracic Tumor Research Institute), Beijing 101149, China
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| Abstract: |
| ［Abstract］ Objective To explore the B7-H3 expression level in small-cell lung cancer(SCLC) and its correlation with the small-cell lung cancer patients′ prognosis. Methods Thirty-four SCLC tissue specimens surgically resected in Beijing Chest Hospital, Capital Medical University from January 2010 to July 2019 were collected, and the medical records and follow-up data of the patients from whom the specimens were obtained were collected. The expression of B7-H3 in the SCLC tissues was detected by using immunohistochemical method, and the correlation between the expression level of B7-H3 in the SCLC tissues and the patients′ clinical characteristics was analyzed. Results There were 14 patients(41.18%) with high expression of B7-H3 and 20 patients(58.82%) with low expression of B7-H3. The expression of B7-H3 was positive in 26 cases(76.47%) and negative in 8 cases(23.53%). The proportion of lymph node metastasis and the number of lymph node metastasis in the high B7-H3 expression group were higher than those in the low B7-H3 expression group, and the differences were statistically significant(P<0.05). However, there were no statistically significant differences in gender, age and smoking ratio between the two groups(P>0.05). Expression of B7-H3 was consistent with score of micro vessel density(MVD)(Kappa=0.339, P=0.048). The MVD scores of the high B7-H3 expression group were higher than those of the low B7-H3 expression group, and the differences were statistically significant(t=3.784, P=0.001). The median overall survival(OS) of the high B7-H3 expression group was shorter than that of the low B7-H3 expression group(13.8 months vs 23.5 months), and the difference in survival prognosis between the two groups was statistically significant(log-rank test: χ2=3.873, P=0.049). Conclusion B7-H3 is expressed to varying degrees in SCLC tissues, and high expression of B7-H3 is associated with lymph node metastasis and poor prognosis, which may become a potential target for treatment of SCLC. |
| Key words: Small-cell lung cancer(SCLC) B7-H3 Prognosis |
