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去甲二氢愈创木酸药理作用及机制的研究进展
高海军1，2，杨丽娟1，莫筱瑾2，3，张　颋2，3，周芳烨1
1.成都市第五人民医院，成都中医药大学附属第五医院/第二临床医学院，四川 611130；2.中国疾病预防控制中心寄生虫病预防控制所（国家热带病研究中心），传染病溯源预警与智能决策全国重点实验室，国家卫生健康委寄生虫病原与媒介生物学重点实验室，世界卫生组织热带病合作中心，上海 200025；3.西藏自治区疾病预防控制中心，国家卫生健康委包虫病防治研究重点实验室，拉萨 850000
摘要:
［摘要］　去甲二氢愈创木酸（NDGA）是从植物常青灌木分叉拉瑞阿中提取的一种化合物。NDGA因其具有抗氧化性而被用于食品加工业。NDGA还被证实具有免疫调节、抗菌、抗病毒、抗肿瘤、抗血管生成、抗生殖和抗纤维化等药理作用，提示NDGA在疾病治疗中具有重要潜在价值。关于NDGA在疾病治疗中的作用及机制尚无系统总结。该文对NDGA药理作用及机制的研究进展作一综述。
关键词:  去甲二氢愈创木酸  氧化应激  抗肿瘤  抗血管生成  抗纤维化
DOI：10.3969/j.issn.1674-3806.2024.12.19
分类号:R 965
基金项目:国家重点研发计划项目（编号：2021YFC2300800）；国家卫生健康委寄生虫病原与媒介生物学重点实验室开放课题项目（编号：NHCKFKT2022-02）；成都市医学科研课题项目（编号：2024041）
Research progress on pharmacological effects and mechanisms of nordihydroguaiaretic acid
GAO Haijun1,2, YANG Lijuan1, MO Xiaojin2,3, ZHANG Ting2,3, ZHOU Fangye1
1.Chengdu Fifth People′s Hospital, the Fifth Affiliated Hospital of Chengdu University of Traditional Chinese Medicine/the Second Clinical Medical College, Sichuan 611130, China; 2.National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research); National Key Laboratory for Early Warning and Intelligent Decision-Making of Infectious Disease Tracing; National Health Commission Key Laboratory of Parasite and Vector Biology; World Health Organization Collaborating Center for Tropical Diseases, Shanghai 200025, China; 3.National Health Commission Key Laboratory of Echinococcosis Prevention and Control, Xizang Center for Disease Control and Prevention, Lhasa 850000, China
Abstract:
［Abstract］　Nordihydroguaiaretic acid(NDGA) is a chemical compound extracted from the evergreen shrub fork Larrea divaricata. NDGA is used in the food processing industry due to the discovery of antioxidant properties in it. NDGA has also been proved to have pharmacological effects such as immune regulation, antibacterial action, antivirus activity, anti-tumor activity, anti-angiogenesis, anti-reproduction and anti-fibrosis, suggesting that NDGA has important potential value in the treatment of diseases. However, the role and mechanism of NDGA in the treatment of diseases have not been systematically summarized at present. In this paper, the research progress on pharmacological effects and mechanisms of NDGA is reviewed.
Key words:  Nordihydroguaiaretic acid(NDGA)  Oxidative stress  Anti-tumor  Anti-angiogenesis  Anti-fibrosis