| 摘要: |
| ［摘要］ 基质作用分子1（STIM1）是位于内质网上的单次跨膜蛋白，能够动态感受细胞内钙浓度变化，随后将钙信号传递给细胞膜上的钙释放激活钙调节蛋白1（ORAI1），诱导下游钙信号和介导细胞钙内流，从而参与细胞增殖和迁移、免疫细胞活化、基因转录等多种生理功能。STIM1/ORAI1信号通路在肺动脉高压、支气管哮喘、慢性阻塞性肺疾病、急性肺损伤/急性呼吸窘迫综合征和特发性肺纤维化等多种呼吸系统疾病中发挥了关键调控作用。该文综述了STIM1/ORAI1信号通路在呼吸系统疾病中的作用及机制的最新研究进展，以期为相关疾病的研究提供更多的思路以及为临床有效诊治寻找可能的研究新靶点。 |
| 关键词: 基质作用分子1 钙释放激活钙调节蛋白1 肺动脉高压 支气管哮喘 慢性阻塞性肺疾病 |
| DOI：10.3969/j.issn.1674-3806.2025.01.04 |
| 分类号:R 563 |
| 基金项目:国家自然科学基金项目（编号：82170056）；广东省自然科学基金项目（编号：2021A1515011024）；广州市科技计划市校联合资助项目（编号：202201020404）；广东省“珠江人才计划”本土创新科研团队项目（编号：2017BT01S155） |
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| The role of STIM1/ORAI1 signaling pathway in pathogenesis of respiratory diseases |
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LIANG Jieping, PENG Gongyong
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Department of Internal Medicine and Department of Pulmonary and Critical Care Medicine, the First Affiliated Hospital of Guangzhou Medical University Hengqin Hospital, Department of Geriatric Medicine, the First Affiliated Hospital of Guangzhou Medical University, National Key Laboratory of Respiratory Diseases, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Health, Guangzhou 510120, China
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| Abstract: |
| ［Abstract］ Stromal interaction molecule 1(STIM1), a single transmembrane protein located in the endoplasmic reticulum, dynamically senses the changes in intracellular calcium concentration and then transmits calcium signals to ORAI calcium release-activated calcium modulator 1(ORAI1) on the cell membrane, inducing downstream calcium signaling and mediating cellular calcium influx, thereby participating in various physiological functions such as cell proliferation and migration, immune cell activation, gene transcription, etc. The STIM1/ORAI1 signaling pathway plays a key regulatory role in a variety of respiratory diseases, including pulmonary hypertension, bronchial asthma, chronic obstructive pulmonary disease, acute lung injury/acute respiratory distress syndrome, and idiopathic pulmonary fibrosis. In this paper, the latest research progress on the role and mechanism of the STIM1/OAI1 signaling pathway in respiratory diseases is reviewed, with the aim of providing more ideas for the studies on the related diseases and finding possible new research targets for effective clinical diagnosis and treatment. |
| Key words: Stromal interaction molecule 1(STIM1) ORAI calcium release-activated calcium modulator 1(ORAI1) Pulmonary hypertension Bronchial asthma Chronic obstructive pulmonary disease |
