| 摘要: |
| ［摘要］ 目的 探讨粪便钙卫蛋白（FCP）辅助诊断儿童上消化道炎症性疾病的临床价值。方法 回顾性分析2023年6月至2024年6月就诊于上海交通大学医学院附属上海儿童医学中心及上海交通大学医学院附属上海儿童医学中心贵州医院消化科的165例患儿的临床资料，分为上消化道炎症性疾病组（66例）和功能性胃肠病组（99例）。采集粪便标本行FCP检测，比较组间差异，并通过受试者工作特征（ROC）曲线评估FCP诊断儿童上消化道炎症性疾病的效能。结果 上消化道炎症性疾病组FCP水平［78.38（16.64，175.70）μg/g］高于功能性胃肠病组［14.90（5.00，33.76）μg/g］，组间差异有统计学意义（Z=5.230，P<0.001）。FCP可辅助诊断儿童上消化道炎症性疾病［AUC（95%CI）=0.74（0.66～0.82），P<0.001］，最佳截断值为96.32 μg/g，灵敏度和特异度分别为50.00%和91.90%。结论 FCP作为一项非侵入性指标，对辅助诊断儿童上消化道炎症性疾病有临床价值。 |
| 关键词: 粪便钙卫蛋白 十二指肠溃疡 慢性胃炎 儿童 |
| DOI：10.3969/j.issn.1674-3806.2025.05.16 |
| 分类号:R 725.7 |
| 基金项目:贵州省卫生健康委科学技术基金项目（编号：gzwkj2024-175） |
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| Clinical value of fecal calprotectin in assisting diagnosis of upper gastrointestinal inflammatory diseases in children |
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WANG Wenyu1,2, LIU Lianhua2, WU Ying3,4, TENG Teng5,6, DENG Zhaohui1
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1.Department of Gastroenterology, Shanghai Children′s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China; 2.Department of Gastroenterology, Guizhou Branch of Shanghai Children′s Medical Center, Shanghai Jiao Tong University School of Medicine, Guiyang 550081, China; 3.Department of Clinical Laboratory, Shanghai Children′s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China; 4.Department of Clinical Laboratory, Guizhou Branch of Shanghai Children′s Medical Center, Shanghai Jiao Tong University School of Medicine, Guiyang 550081, China; 5.Department of Critical Care Medicine, Shanghai Children′s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China; 6.Department of Critical Care Medicine, Guizhou Branch of Shanghai Children′s Medical Center, Shanghai Jiao Tong University School of Medicine, Guiyang 550081, China
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| Abstract: |
| ［Abstract］ Objective To explore the clinical value of fecal calprotectin(FCP) in assisting diagnosis of upper gastrointestinal inflammatory diseases in children. Methods The clinical data of 165 pediatric patients who visited their doctors in Shanghai Children′s Medical Center, Shanghai Jiao Tong University School of Medicine and Department of Gastroenterology, Guizhou Branch of Shanghai Children′s Medical Center, Shanghai Jiao Tong University School of Medicine from June 2023 to June 2024 were retrospectively analyzed. The pediatric patients were divided into upper gastrointestinal tract inflammatory disease group(66 cases) and functional gastrointestinal disease group(99 cases). Fecal samples were collected for detection of FCP, and the differences between groups were compared. Receiver operating characteristic(ROC) curve was used to evaluate the efficacy of FCP in diagnosing upper gastrointestinal tract inflammatory disease in the children. Results The level of FCP in the upper gastrointestinal tract inflammatory disease group［78.38(16.64,175.70)μg/g］ was higher than that in the functional gastrointestinal disease group［14.90(5.00, 33.76)μg/g］, with a statistically significant difference between the two groups(Z=5.230, P<0.001). FCP could assist diagnosis of upper gastrointestinal tract inflammatory disease in the children［AUC(95%CI)=0.74(0.66-0.82), P<0.001］ with the optimum cut-off value of 96.32 μg/g, and the diagnostic sensitivity and specificity were 50.00% and 91.90%, respectively. Conclusion FCP, as a non-invasive indicator, has clinical value in the auxiliary diagnosis of upper gastrointestinal tract inflammatory disease in children. |
| Key words: Fecal calprotectin(FCP) Duodenal ulcer Chronic gastritis Children |
