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氧化应激在类风湿关节炎与抑郁症共病机制中的研究进展
程芳芳1，易梦琳1，王婷婷2，吴建红2
1.川北医学院临床医学院，南充 637000；2.达州市中心医院风湿免疫科，达州 635000
摘要:
［摘要］　类风湿关节炎（RA）与抑郁症在临床上常常共病，二者具有共同的危险因素及病理机制。氧化应激是指体内活性氧（ROS）及其相关代谢产物的过度积累与机体抗氧化能力不足之间的失衡，这种失衡可导致组织损伤并引发疾病。氧化应激在RA及抑郁症的病理机制中扮演着重要的角色。该文对氧化应激在RA与抑郁症共病机制中的研究进展作一综述。
关键词:  氧化应激  类风湿关节炎  抑郁症  共病
DOI：10.3969/j.issn.1674-3806.2025.05.23
分类号:R 593.2
基金项目:四川省医学科研课题计划项目（编号：S23001）
Research progress in mechanism of oxidative stress in comorbidity of rheumatoid arthritis and depression
CHENG Fangfang1, YI Menglin1, WANG Tingting2, WU Jianhong2
1.College of Clinical Medicine, North Sichuan Medical College, Nanchong 637000, China; 2.Department of Rheumatology and Immunology, Dazhou Central Hospital, Dazhou 635000, China
Abstract:
［Abstract］　Rheumatoid arthritis(RA) and depression often become comorbidity in clinical practice, and RA and depression have some common risk factors and pathological mechanisms. Oxidative stress refers to the imbalance between the excessive accumulations of reactive oxygen species in the body and their related metabolites and the insufficient antioxidant capacity of the body. This imbalance can lead to tissue damage and cause diseases. Oxidative stress plays an important role in the pathological mechanisms of RA and depression. In this paper, the research progress in the mechanism of oxidative stress in the comorbidity of rheumatoid arthritis and depression is reviewed.
Key words:  Oxidative stress  Rheumatoid arthritis(RA)  Depression  Comorbidity