| 摘要: |
| ［摘要］ 目的 分析化疗对远处转移鼻咽癌患者生存预后的影响。方法 回顾性分析2010年6月至2019年6月广西壮族自治区人民医院收治的发生远处转移的187例鼻咽癌患者的临床资料和随访资料。其中有100例愿意接受化疗（化疗组），87例放弃化疗（非化疗组）。通过生存曲线以及Cox回归分析转移部位、化疗方案、化疗周期等因素对患者生存预后的影响。结果 截至2020年1月，非化疗组死亡82例，化疗组死亡70例，化疗组生存预后显著优于非化疗组（log-rank检验： χ2=9.565，P=0.002）。对于接受化疗者，多因素Cox回归分析结果显示，以肺转移为参照，肝转移［RR（95%CI）=2.823（1.284～6.210）］和多处转移［RR（95%CI）=3.920（2.118～7.255）］是患者生存预后不良的独立危险因素（P<0.05）；以化疗周期≤4周期为参照，化疗周期>4周期［RR（95%CI）=0.276（0.142～0.536）］是促进患者获得更好生存预后的独立保护因素（P<0.05）。结论 化疗可显著改善远处转移鼻咽癌患者生存预后，转移部位和化疗周期是影响生存预后的重要因素。 |
| 关键词: 鼻咽癌 远处转移 化疗 生存预后 |
| DOI：10.3969/j.issn.1674-3806.2025.11.15 |
| 分类号:R 739.62 |
| 基金项目:广西重点研发计划项目（编号：桂科AB25069036） |
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| Effects of chemotherapy on survival prognosis of patients with distant metastatic nasopharyngeal carcinoma: a retrospective cohort study |
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QIN Yangda, LI Min, WANG Yongli, HUANG Bo, XIE Sifang, WENG Jingjin
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Department of Otolaryngology and Head and Neck, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To analyze the effects of chemotherapy on survival prognosis of patients with distant metastatic nasopharyngeal carcinoma. Methods A retrospective analysis was conducted on the clinical data and follow-up data of 187 patients with distant metastatic nasopharyngeal carcinoma who were admitted to the People′s Hospital of Guangxi Zhuang Autonomous Region from June 2010 to June 2019. Among them, 100 patients were willing to receive chemotherapy(chemotherapy group), and 87 patients abandoned chemotherapy(non-chemotherapy group). The effects of factors such as metastatic sites, chemotherapy regimens and chemotherapy cycles on the patients′ survival prognosis were analyzed by using survival curve and Cox regression. Results By January 2020, 82 patients in the non-chemotherapy group and 70 patients in the chemotherapy group died. The survival prognosis of the patients in the chemotherapy group was significantly better than that of the patients in the non-chemotherapy group(log-rank test: χ2=9.565, P=0.002). For the patients receiving chemotherapy, the results of multivariate Cox regression analysis showed that, with lung metastasis as a reference, liver metastasis［RR(95%CI)=2.823(1.284-6.210)］ and multiple metastases［RR(95%CI)=3.920(2.118-7.255)］ were independent risk factors for poor survival prognosis in them(P<0.05); with chemotherapy cycles ≤4 cycles as a reference, chemotherapy cycles >4 cycles［RR(95%CI)=0.276(0.142-0.536)］ were independent protective factors for promoting better survival prognosis in them(P<0.05). Conclusion Chemotherapy can significantly improve the survival prognosis of patients with distant metastatic nasopharyngeal carcinoma. Metastatic site and chemotherapy cycle are important factors affecting the patients′ survival prognosis. |
| Key words: Nasopharyngeal carcinoma Distant metastasis Chemotherapy Survival prognosis |
