引用本文:
【打印本页】   【下载PDF全文】   【View/Add Comment】  【EndNote】   【RefMan】   【BibTex】
←前一篇|后一篇→ 过刊浏览    高级检索
本文已被：浏览 117次   下载 79次 本文二维码信息
码上扫一扫！
分享到： 微信 更多
字体:加大+|默认|缩小-
肠道微生物菌群失调对类风湿性关节炎影响的研究进展
邵兴琴1，罗宇涵1，张　浪1，袁　静2，查　艳2，林　鑫1，2
1.遵义医科大学第一临床学院，遵义 563003；2.国家卫生健康委员会肺脏免疫性疾病诊治重点实验室，贵州省常见慢性疾病发病机制及防治研究全省重点实验室，贵州省人民医院肾内科，贵阳 550002
摘要:
［摘要］　类风湿性关节炎（RA）是一种由遗传和环境因素共同作用引发的慢性全身性免疫介导性疾病，以自身抗体产生为特征，导致外周关节对称性病变。临床上主要表现为肿胀、晨僵及持续性疼痛。近年来，多项研究表明，RA患者的肠道微生物菌群组成与健康者比较存在显著差异。该文对肠道微生物菌群失调对RA影响的研究进展作一综述。
关键词:  类风湿性关节炎  炎症  肠道微生物菌群失调  发病机制
DOI：10.3969/j.issn.1674-3806.2026.04.18
分类号:
基金项目:贵州省卫生健康委员会重点优势学科培育项目
Research progress in the effects of gut microbiota imbalance on rheumatoid arthritis
SHAO Xingqin1, LUO Yuhan1, ZHANG Lang1, YUAN Jing2, ZHA Yan2, LIN Xin1,2
1.The First Clinical College, Zunyi Medical University, Zunyi 563003, China; 2.Department of Nephrology, Guizhou Provincial People′s Hospital, National Health Commission Key Laboratory for Diagnosis and Treatment of Pulmonary Immune Diseases, Guizhou Provincial Key Laboratory for Research on Pathogenesis, Prevention and Treatment of Common Chronic Diseases, Guiyang 550002, China
Abstract:
［Abstract］　Rheumatoid arthritis(RA) is a chronic systemic immune-mediated disease caused by the combined effect of genetic and environmental factors, characterized by the production of autoantibodies, resulting in symmetrical lesions of peripheral joints. The main clinical manifestations of RA include joint swelling, morning stiffness and persistent pain. In recent years, some studies show that the composition of the gut microbiota in RA patients is significantly different from that in healthy people. In this paper, the research progress in the effects of gut microbiota imbalance on RA is reviewed.
Key words:  Rheumatoid arthritis  Inflammation  Gut microbiota imbalance  Pathogenesis