| 摘要: |
| ［摘要］ 目的 探讨同种异体骨联合富血小板纤维蛋白（PRF）重建严重缺损牙槽骨的效果。方法 回顾性分析2021年10月至2024年9月于广西中医药大学第一附属医院口腔科接受同种异体骨联合PRF重建牙槽骨治疗的30例牙槽骨严重缺损患者（观察组）的临床资料。以年龄、性别、体质量指数（BMI）、病程、缺损部位及缺损牙位数为匹配条件，纳入接受同种异体骨重建牙槽骨治疗的30例牙槽骨严重缺损患者（对照组）的临床资料。比较两组牙槽骨形态学指标、种植体稳定性（ISQ）、种植体功能负荷后周围软组织情况及不良反应发生情况。结果 两组术后6个月的牙槽骨高度、宽度及骨密度均较术前显著增加（P<0.05），且观察组指标水平大于对照组，差异有统计学意义（P<0.05）。与种植体植入即刻相比，观察组种植体植入后3个月的ISQ显著升高（P<0.05），对照组指标水平无显著改变（P>0.05）。观察组种植体植入后3个月的ISQ亦显著高于对照组（P<0.05）。在种植体功能负荷后3个月，观察组探诊深度（PD）、牙龈退缩量（GR）、牙龈指数（GI）水平低于对照组，角化龈宽度（KTW）高于对照组，差异有统计学意义（P<0.05）。在术后1年内，对照组和观察组分别有4例（13.33%）和2例（6.67%）发生不良反应，差异无统计学意义（χ2=0.741，P=0.389）。结论 对于严重缺损牙槽骨，同种异体骨联合PRF可更显著地改善牙槽骨形态与骨密度，提升种植体稳定性，改善周围软组织状态，安全性好，值得临床推荐。 |
| 关键词: 牙槽骨严重缺损 同种异体骨 富血小板纤维蛋白 脱细胞真皮基质 种植体稳定性 |
| DOI：10.3969/j.issn.1674-3806.2026.08.14 |
| 分类号:R 783.6 |
| 基金项目:广西卫生健康委员会科研课题（编号：Z-A20240786） |
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| Clinical study on the reconstruction of severe alveolar bone defects using allogeneic bone combined with platelet-rich fibrin |
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Wu Jing1, Yang Yuan2, Huang Dingyang1, Yao Yingbing1, Huang Meijuan1, Liu Xiaoxia1, Wang Ling1
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1.Department of Dentistry, the First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China; 2.Department of Orthopedics, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To explore the efficacy of allogeneic bone combined with platelet-rich fibrin(PRF) in reconstructing severe alveolar bone defects. Methods A retrospective analysis was conducted on the clinical data of 30 patients with severe alveolar bone defects who received allogeneic bone combined with PRF for reconstructing alveolar bone(observation group) in Department of Dentistry, the First Affiliated Hospital of Guangxi University of Chinese Medicine from October 2021 to September 2024. A total of 30 patients with severe alveolar bone defects who received alveolar bone reconstruction using allogeneic bone were enrolled as control group, matched by age, sex, body mass index(BMI), disease duration, defect location and the number of affected teeth. The morphological indicators of the alveolar bone, implant stability quotient(ISQ), soft tissue conditions around the implant functional load, and the occurrence of adverse reactions were compared between the two groups. Results At 6 months post-surgery, both groups exhibited significant increases in alveolar bone height, width, and bone density compared to pre-surgery levels(P<0.05), and these indicators in the observation group were greater than those in the control group after surgery, with statistically significant differences between the two groups(P<0.05). Compared with that immediately after implant placement, ISQ in the observation group significant increased at 3 months post-surgery(P<0.05), while the indicator in the control group did not change significantly at 3 months post-surgery(P>0.05). At 3 months post-implantation, ISQ in the observation group was also significantly higher than that in the control group(P<0.05). The observation group had lower levels of probing depth(PD), gingival recession(GR) and gingival index(GI), and higher levels of keratinized tissue width(KTW) than the control group 3 months after implant functional loading, with statistically significant differences(P<0.05). Within 1 year post-surgery, 4 cases(13.33%) in the control group and 2 cases(6.67%) in the observation group experienced adverse reactions, with no statistically significant difference between the two groups(χ2=0.741, P=0.389). Conclusion For severe alveolar bone defects, allogeneic bone combined with PRF can significantly improve the morphology and bone density of the alveolar bones, enhance implant stability, and improve the condition of surrounding soft tissue. The combined treatment is safe and worthy of clinical recommendation. |
| Key words: severe alveolar bone defects allogeneic bone platelet-rich fibrin(PRF) acellular dermal matrix implant stability |
