| 摘要: |
| ［摘要］ 交感神经活性增高是心力衰竭、难治性高血压及阻塞性睡眠呼吸暂停等疾病的重要共同病理生理特征。颈动脉体（CB）敏化表现为外周化学反射敏感性增强，伴随交感神经活性增高。相关机制涉及氧化应激与炎症反应、局部肾素-血管紧张素系统失衡、灌注异常及代谢信号异常等。目前CB靶向干预已显示出转化潜力，但相关药物干预的证据仍以临床前研究和早期探索性研究为主，尚不足以支持常规临床应用。该文对CB在交感神经活性增高相关疾病中作用的研究进展作一综述。 |
| 关键词: 颈动脉体 外周化学反射 交感神经活性增高 心力衰竭 难治性高血压 阻塞性睡眠呼吸暂停 |
| DOI：10.3969/j.issn.1674-3806.2026.08.20 |
| 分类号:R 54 |
| 基金项目:国家自然科学基金资助项目（编号：32127802） |
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| Role of carotid body in diseases associated with heightened sympathetic nervous system activity: a review |
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Wu Ruoyu, Huang Jing
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1.Inner Mongolia Medical University, Hohhot 010020, China; 2.Department of Pediatrics, Inner Mongolia People′s Hospital, Hohhot 010010, China
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| Abstract: |
| ［Abstract］ Heightened sympathetic nervous system activity is a significant common pathophysiological feature of diseases such as heart failure,resistant hypertension and obstructive sleep apnea. Carotid body(CB) sensitization manifests as enhanced peripheral chemoreflex sensitivity, accompanied by heightened sympathetic nervous system activity. The underlying mechanisms involve oxidative stress and inflammatory responses, imbalance of the local renin-angiotensin system, abnormal perfusion, and abnormal metabolic signals. At present, CB-targeted interventions have shown translational potential, but the evidence for related drug interventions is still mainly from preclinical studies and early exploratory studies, which is not yet sufficient to support routine clinical applications.In this paper, the role of CB in diseases associated with heightened sympathetic nervous system activity is reviewed. |
| Key words: carotid body(CB) peripheral chemoreflex heightened sympathetic nervous system activity heart failure resistant hypertension obstructive sleep apnea |
