| 摘要: |
| ［摘要］ 目的 探讨血管紧张素转换酶抑制剂(ACEI)依那普利与醛固酮受体拮抗剂(ARA)安体舒通联合治疗慢性心力衰竭的近期疗效。方法 慢性心力衰竭患者共95例，随机分为两组，两组疗程皆四周。对照组43例，予以地高辛0.125～0.25 mg, 1次/d，氢氯噻嗪25mg，1～2次/d，皆口服；治疗组52例在对照组治疗的基础上，加用依那普利5～10 mg, 1次/d，安体舒通20mg，2次/d，仍口服。4周后观察两组疗效及左心功能，包括每搏输出量（SV）、心输出量（CO）、左室射血分数（LVEF）改变情况。结果 治疗组的疗效及症状、体征改善均优于对照组(P<0.01），总有效率为94.2%，而对照组则为72.1%。左心功能亦较对照组明显改善，具有显著性差异（P<0.01）。结论 依那普利与安体舒通联合治疗慢性心衰有较佳的近期疗效，具有安全性大 、使用方便、价格低廉、患者易接受的优点，值得临床推广运用。 |
| 关键词: 依那普利 安体舒通 心力衰竭 |
| DOI： |
| 分类号:R 541.6 |
| 基金项目: |
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| Recent curative effect of combining enalapril with aldactone in the treatment of chronic heart failure |
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HUANG Zhong-guo, LI Jin-wei, SHAO Yong-jian, et al.
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Chang Shou Traditional Chinese Medicine Hospital, Chongqing 401220, China
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| Abstract: |
| ［Abstract］ Objective To explore the recent curative effect of combining ACEI—enalapril with ARA-aldactone in the treatment of chronic heart failure. Methods Ninety-five patients with chronic heart failure were randomly divided into two groups.The control group(n=43) were given oral digoxin 0.125～0.25mg once daily, hydrodiuril 25mg once or twice daily. The treatment group(n=52) were given oral enalapril 5～10mg once daily and aldactone 20mg twice daily on the basis of same therapy used in control group. The therapeutic course of the both groups was four weeks.The therapeutic efficacy before and after therapy are compared between two groups, so did the changes of function of left ventricl(SV, CO and LVEF). Results The curative effect in treatment group was superior to that in control group(P<0.01). The total effective rate of treatment group was 94.2%，while the total effective rate of control group was 72.1%, and the symptoms and signs of treatmet group were obviously improved(P<0.01). The changes of function of left ventricl(SV, CO and LVEF) before and after therapy also had significant difference between treatment group and control group(P<0.01). Conclusion The treatment combining enalapril with aldactone for chronic heart failure is more effective in the near future. This method is safe, cheap and convenient which is worthy of spreading to application in clinical work. |
| Key words: Enalapril Aldactone Chronic heart failure |
