| 摘要: |
| ［摘要］ 目的 观察FOLFOX4方案治疗晚期胃癌的近期疗效和毒副反应。方法 30例晚期胃癌患者，先给予FOLFOX4方案，即：奥沙利铂（L-OHP）85 mg/m2静脉点滴2 h，d1;亚叶酸钙（CF）200 mg/m2静脉点滴2 h，d1、d2，随后5-氟尿嘧啶（5-FU）400 mg/m2静脉推注，d1、d2，5-FU 600 mg/m2微泵持续滴注22 h, d1、d2。2周重复。4个周期后以WHO评价标准评价疗效和毒性。结果 全组30例均可评价，其中完全缓解（CR）2例，部分缓解（PR）16例，稳定（SD）7例，进展（PD）5例，总有效率（CR+PR）60%。中位肿瘤进展时间（TTP）5.5月，中位生存时间（MST）为9个月。毒副反应主要是骨髓抑制，白细胞降低发生率达83.3%，其次为胃肠道反应，恶心呕吐发生率为80.0%，口腔粘膜炎为21.3%，腹泻36.7%，无Ⅳ度胃肠道反应，周围神经毒性发生率为50.0%。结论 FOLFOX4方案治疗晚期胃癌的近期疗效较好，毒副反应可以耐受，值得进一步研究应用。 |
| 关键词: 晚期胃癌 奥沙利铂 亚叶酸钙 5-氟尿嘧啶 化疗 |
| DOI： |
| 分类号:R 735.2 |
| 基金项目: |
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| Clinical study of advanced gastric cancer patients treated with leucovorin, 5-fluorouracil and oxaliplatin (FOLFOX4) chemotherapy |
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ZHANG Bo
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Department of Oncology, Guannan People, s Hospital, Guannan 222500, China
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| Abstract: |
| ［Abstract］ Objective To evaluate the efficacy and adverse effects of oxaliplatin combined with 5-fluorouracil(5-FU) and calcium folinate in the treatment of patients with advanced gastric cancer.Methods Thirty patients with advanced gastric cancer received chemotherapy of regimen L-OHP 85 mg/m2 2 hours d1, CF 200 mg/m2 2 hours d1, d2, followed by 5-FU 400 mg/m2 iv and 600 mg/m2 22 hours civ d1, d2, two weeks as one cycle. Efficacy was evaluated after 4 cycles.Results Two patients achieved complete response (CR), 16 patients partial response (PR), 7 patients stable disease (SD), 5 patients progression disease (PD).Total effective rate was 60%. The major toxicity included nausea, vomiting, leucopenia and neurosensory.Conclusion This study shows that the regimen of FOLFOX4 is effective and tolerable in advanced gastric cancer. |
| Key words: Advanced gastric cancer Oxaliplatin Calcium folinate 5-Fluorouracil Chemotherapy |
