| 摘要: |
| ［摘要］ 目的 观察低分子肝素（low-molecular-weight heparin, LMWH）在不同时间窗治疗脑梗死（cerebral infarction, CI）的临床疗效。方法 75例入组患者按起病至治疗开始时间分为A组（<24 h）、B组（24～48 h）、C组（49 h～7 d），每组25例。3组患者均使用LMWH 5000抗XaIU腹壁皮下注射，2次/d，共7 d，于治疗前、治疗后第8天进行神经功能缺损程度评分和疗效评定。结果 3组患者治疗后的神经功能缺损评分均降低（P<0.05），治疗前后神经功能缺损评分差值比较差异有统计学意义（P<0.05），A组大于C组（P<0.01）；3组总有效率比较差异有统计学意义（P<0.05），A组高于C组（P<0.05）。结论 LMWH在不同时间窗均可改善CI患者的神经功能缺损和预后，其疗效以24 h内为佳。 |
| 关键词: 时间窗 低分子肝素 脑梗死 神经功能缺损 |
| DOI： |
| 分类号:R 587.1 |
| 基金项目: |
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| Therapeutic effects of low-molecular-weight heparin in treatment of cerebral infarction in different time windows |
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QIN Cong-jun, JIANG Shun-jian, LIAO Jun
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Department of Internal Medicine, the People′s Hospital of Gongcheng County, Guilin 542500, China
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| Abstract: |
| ［Abstract］ Objective To observe the therapeutic effects of low-molecular-weight heparin (LMWH) in treatment of cerebral infarction (CI) in different time windows.Methods According to the admitted date, 75 selected patients with CI were randomly divided into three groups: A group (<24h), B group (24～48h) and C group (49h～7d). All patients in three groups were treated with abdominal subcutaneous injection of LMWH 5000 IU, twice daily for 7days. The neurologic impairment score and effectiveness of three study groups were evaluated before treatment and the 8th day after the treatment.Results The neurologic impairment score of three groups were significantly decreased after the treatment of LMWH (P<0.05 orP<0.01). Significant difference were found in the neurologic impairment score differences before and after treatment in three groups(P<0.05), and the differences of A group was bigger than those of C group(P<0.05). In three group, significant difference were also found in the total effective rate(P<0.05), and the the total effective rate of A group was higher than that of C group(P<0.05).Conclusion LMWH could effectively improve neurologic impairment and prognosis of patients with CI in different time windows especially in 24 hours. |
| Key words: Time windows Low-molecular-weight heparin Cerebral infarction Neurologic impairment |
