| 摘要: |
| ［摘要］ 目的 探讨双水平气道正压无创机械通气(BiPAP)对慢性阻塞性肺疾病(COPD)合并Ⅱ型呼吸衰竭早期患者肺功能、血气分析、功能性呼吸困难分级的影响。方法 对100例慢性阻塞性肺疾病急性发作期（AECOPD）合并Ⅱ型呼吸衰竭患者分为常规对照组(A组)和无创通气治疗组（B组），其中A组48例，B组52例；A组与B组在治疗前及治疗后第3天均分别作肺功能测定、呼吸困难指数评分；在治疗前，治疗后2、4、8、72 h分别作血气分析、每分钟呼吸频率（RR）测定。结果 (1)B组与A组比较，肺功能及呼吸困难指数均明显改善（P<0.05）。(2)B组在治疗后4小时血气分析pH、PCO2、PO2及RR均改善（P<0.05），8 h后更明显（P<0.01），72 h呼吸衰竭已基本纠正（P<0.01）。结论 双水平气道正压无创机械通气能明显改善AECOPD患者肺功能、呼吸困难指数，较快纠正Ⅱ型呼吸衰竭，是治疗早期呼吸衰竭的一个重要手段。 |
| 关键词: 慢性阻塞性肺疾病 急性发作期 Ⅱ型呼吸衰竭 无创机械通气 |
| DOI：10.3969/j.issn.1674-3806.2009.03.018 |
| 分类号:R 563.8 |
| 基金项目: |
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| Observatinon on therapeutic effect of bi-level positive airway pressure noninvasive ventilation on 52 cases of chronic obstructive pulmonary disease with type II respiratory failure |
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LI Yong-pu, YANG Mei, XIA Wei, et al.
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Department of Respiration, People′s Hospital of Chang Shou, Chongqing 401220, China
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| Abstract: |
| ［Abstract］ Objective To investigate the effect of bi-level positive airway pressure noninvasive ventilation(BiPAP) on the lung function, blood gas analysis and dyspnea score of patients with chronic obstructive pulmonary disease with type Ⅱ respiratory failure. Methods one hundred patients with COPD complicating by respiratory failure were randomly divided into control group(groupA, n=48) and treated group(groupB, n=52).Lung function tests were performed, and dyspnea score were counted before treatment and after three days of treatment; Respiratory frequency was observed and blood gas parameters including pH, PO2, PCO2 were recorded before treatment and after two hour, four hour, eight hour, seventy-two hour of threatment.Results (1)compared with groupA, dyspnea score in group B decreased and lung function were improved(P<0.05). (2)The values of PH and PO2 greatly improved and PCO2 significantly decreased in group B after four hour of threatment（P<0.05） and after eight hour of threatment（P<0.01）, and respiratory failure were rectified after seventy-two hour of threatment（P<0.01）.Conclusion Using BiPAP respiratory machine assistant ventilation can improve lung function, decrease dyspnea score, and rectify rapidly respiratory failure, and it were effective for patients with COPD complicating by respiratory failure. |
| Key words: Chronic obstructive pulmonary disease Acute exacerbation Type II respiratory failure Noninvasive ventilation |
