| 摘要: |
| ［摘要］ 目的 探讨新辅助化疗结合肢体保肢手术治疗骨肉瘤的临床疗效。方法 对33例四肢骨肉瘤患者进行保肢治疗,其中21例完成术前、后新辅助化疗；10例因各种原因未能完成术后化疗。按Enneking分期,ⅠB期5例,ⅡA期7例,ⅡB期19例。施行人工关节置换术15例,瘤段截除灭活再植术11例，异体骨移植5例。所有病例均做切除标本病理切片的坏死率评估。结果 随访时间9～78个月,平均36个月。肢体功能重建评估优9例,良15例,可5例,差2例,优良率72.7%。结论 保肢手术结合新辅助化疗是治疗肢体骨肉瘤的比较理想的方法,有效的术前化疗是保肢成功的关键,坚持术后化疗是预防肺转移的有效措施。 |
| 关键词: 骨肉瘤治疗 新辅助化疗 保肢手术 |
| DOI：10.3969/j.issn.1674-3806.2010.03.25 |
| 分类号:R 738.1 |
| 基金项目: |
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| New adjuvant chemotherapy combined with limb salvage surgery for limb osteosarcoma: analysis of 33 cases |
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YUAN Hua-jun
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Yulin Orthopedic Hospital, Guangxi 537000, China
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| Abstract: |
| ［Abstract］ Objective To study the clinical curative effect of new adjuvant chemotherapy combined with limb salvage surgery for limb osteosarcoma.Methods Thirty-three patients with limb osteosarcoma were treated by limb salvage. Among those patients, new adjuvant chemotherapy before and after surgery were completed in 21 patients. And because of various reason, the chemotherapy can not be completed in 10 patients after operation. According to Enneking Staging,ⅡA stage was 7 patients; ⅡB stage 19;ⅠB stage 5.Results The follow-up time was 9～78 months, with an average of 36 months. The limbs function reconstruction valuation demonstrated, excellent in 9, good in 15, fair in 5, poor in 2, the excellent and good rate was 72.7%.Conclusion Combined limb salvage surgery with new adjuvant chemotherapy is the more ideal treatment method for osteosarcoma. The valid chemotherapy before the surgical operation is the key of the successful limb salvage. |
| Key words: Osteosarcoma New adjuvant chemotherapy Limbs salvage surgery |
