| 摘要: |
| ［摘要］ 目的 研究不同剂量阿托伐他汀对不稳定性心绞痛患者治疗后炎症因子、调脂疗效的影响。方法 对50例不稳定性心绞痛患者，随机分为阿托伐他汀10 mg组（A组）24例，20 mg组（B组）26例，分别于治疗前和治疗3个月后空腹采血测定血清高敏C-反应蛋白（hs-CRP）和肌钙蛋白I（CTnI）浓度以及血脂水平。结果 阿托伐他汀20 mg组较10 mg组治疗后hs-CRP和CTnI浓度降低更明显（P<0.01）。两组服药后血脂水平较服药前均有降低，但阿托伐他汀20 mg组较10 mg组治疗后血清低密度脂蛋白（LDL-C）浓度降低更明显（P<0.05）。结论 不稳定性心绞痛患者血清hs-CRP和CTnI水平较正常人升高；阿托伐他汀能降低不稳定性心绞痛患者血清hs-CRP和CTnI、LDL-C水平；20 mg阿托伐他汀治疗较10 mg阿托伐他汀治疗疗效更好。 |
| 关键词: 不稳定心绞痛 阿托伐他汀 C-反应蛋白 肌钙蛋白 低密度脂蛋白 |
| DOI：10.3969/j.issn.1674-3806.2010.05.21 |
| 分类号:R 541.4 |
| 基金项目: |
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| Effects different doses of atorvastatin on serum C-reactive protein,troponin and LDL-C in the patients with uinstable angina pectoris |
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HE Xiao-song
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Department of Clinical Medicine,Hunan Provincial Water Resources and Hydropower Hospital,Changsha 410007,China
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| Abstract: |
| ［Abstract］ Objective To study the impact of different doses of atorvastatin on inflammatory cytokines and lipid-lowering efficacy of patients with unstable angina pectoris.Methods Fifty patients with unstable angina were randomly divided into atorvastatin 10 mg group (A group,24 cases), 20 mg group (B group, 26 cases), before treatment and after 3 months of the treatment fasting blood samples were collected and the concentrations of serum high-sensitivity C-reaction protein (hs-CRP) and troponin I (CTnI) and the levels of serum lipid were measured.Results After treatment, compared with A group, concentrations of hs-CRP and CTnI lowed more obviously in B group(P<0.01), and levels of lipid lowered in both of the two groups, but the decrease of the level of LDL-C in B group was more obvious than A group (P<0.05). Conclusion Levels of CTnT and hs-CRP of patients with unstable angina pectoris are high. Atorvastatin can lower levels of hs-CRP, CTnI and LDL-C of patients with unstable angina pectoris, and 20 mg atorvastatin has better efficacy compared with 10 mg atorvastatin. |
| Key words: Unstable angina pectoris Atorvastatin C-reactive protein Troponin Low-density lipoprotein |
