| 摘要: |
| ［摘要］ 目的 探讨糖皮质激素（GC）对新发病重症肌无力(MG)患者外周血B淋巴细胞刺激因子（BAFF）、白介素6（IL-6）水平及临床疗效的影响。方法 采用ELISA法检测26例MG患者GC治疗前、后及正常对照组血清BAFF、IL-6水平，并观察GC治疗的临床效果。结果 MG患者外周血清IL-6、BAFF水平明显高于正常对照组水平（P<0.05），激素治疗2个月后，MG患者外周血BAFF、IL-6水平显著下降（t=9.79 or t=3.45，P<0.01），治疗前后IL-6变化与肌无力相对评分存在显著正相关性（r=0.559，P<0.01）。结论 MG患者血清IL-6水平可能与病情严重程度呈正相关，GC可通过抑制IL-6、BAFF分泌，有效调节MG患者细胞免疫功能。 |
| 关键词: 重症肌无力 糖皮质激素 白介素6 B淋巴细胞刺激因子 |
| DOI：10.3969/j.issn.1674-3806.2011.02.04 |
| 分类号:R 746.1 |
| 基金项目:广西自然科学基金资助项目（编号：桂科自0339028）；广西卫生厅中医药科技专项重点项目（编号：GZKZ10-012） |
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| Effects of glucocorticoid therapy on the sera levels of IL-6 and BAFF in patients with myasthenia gravis |
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WANG Min-li, LI Xiao-feng,ZHANG Li-xiang,et al.
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Department Neurology, Uion Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022，China
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| Abstract: |
| ［Abstract］ Objective To investigate the effect of glucocorticoid(GC) therapy on the sera levels of interleukin-6(IL-6) and B cell activating factor (BAFF) and the clinical efficacy in new onset patients with myasthenia gravis(MG).Methods The sera levels of IL-6 and BAFF were measured in 26 patients with MG before and after-treatment and in 30 normal controls (NC) with ELISA. The effects of GC on patients with MG were assessed by XU Xian-hao score system.Results The levels of IL-6 and BAFF of patients with MG were significantly higher than those of NC group（P<0.05）. The sera levels of IL-6 and BAFF were dramatically decreased after 2 months of treatment with GC. There were significant positive correlation between variation of IL-6 concentrations and the relative scores of MG before and after-treatment. Conclusion The level of IL-6 were significantly positively correlated with the severity of MG, GC can effectively regulate the function of cellular immunity by inhibiting the production of IL-6 and BAFF. |
| Key words: Myasthenia gravis Glucocorticoid BAFF IL-6 |
