| 摘要: |
| ［摘要］ 目的 观察阿托伐他汀对老年早期糖尿病肾病患者外周血单个核细胞中核因子-κB(NF-κB)P65的磷酸化水平和血清hs-CRP、TNF-α、IL-6、IL-1β炎症因子以及胰岛素抵抗的影响。方法 选择66例老年早期2型糖尿病患者随机分为糖尿病常规治疗组（对照组,n=31）及糖尿病常规治疗联合阿托伐他汀干预组（治疗组,n=35），比较两组治疗前后NF-κB、血清hs-CRP、TNF-α、IL-6、IL-1β及胰岛素抵抗指数（HOMA-IR）的变化。结果 治疗12周后，治疗组外周血NF-κB水平、血清炎症因子、HOMA-IR显著下降（P<0.05）,对照组无明显变化(P>0.05)。结论 阿托伐他汀可降低糖尿病肾病患者炎症水平，改善胰岛素抵抗。 |
| 关键词: 阿托伐他汀 糖尿病肾病 核因子-κB 胰岛素抵抗 |
| DOI：10.3969/j.issn.1674-3806.2011.05.03 |
| 分类号:R 587.2 |
| 基金项目:广西科技厅青年科学基金资助项目（编号：0991062） |
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| Effect of atorvastatin on nuclear factor κB activity in peripheral blood mononuclear cell and insulin resistance in type 2 diabetes mellitus elderly patients with early nephropathy |
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LI Jian-ying，WANG Zhi-ying，CHEN Jian，et al.
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Senior Officials inpatient Ward,the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To observe effect of atorvastatin on nuclear factor κB(NF-κB) activity in peripheral blood mononuclear cell,as well as serum inflammation factors including high sensitivity C reactive protein (hs-CRP)，tumor necrosis factor-a (TNF-a)，interleukin-6(IL-6), interleukin-1β(IL-1β) and insulin resistance in type 2 diabetes mellitus elderly patients with early nephropathy.Methods There were 66 type 2 diabetics with early nephropathy in this study. Diabetics randomly divided into two group: type 2 diabetic routine treatment group (control group,n=31) and type 2 diabetic routine treatment combined with atorvastatin (treatment group,n=35). Level of NF-κB, inflammation factors and HOMA-IR were compared between pre-treatment and post-treatment in two groups.Results After twelve weeks of treatment, level of NF-κB, inflammatory factors and HOMA-IR were significantly decreased in treatment group(P<0.05). Those were not decreased in control group (P>0.05).Conclusion Atorvastatin might benefit patients with diabetes mellitus by improving inflammatory state,as well as insulin resistance. |
| Key words: Atorvastatin Diabetic nephropathy NF-κB Insulin resistance |
