| 摘要: |
| ［摘要］ 目的 了解妊娠期糖尿病（GDM）孕妇血清视黄醇结合蛋白4（RBP4）水平变化及临床意义。方法 采用酶联免疫吸附试验（ELISA）测定50例孕晚期GDM孕妇及50例正常孕晚期孕妇血清RBP4水平，同时测定两组孕妇空腹血糖（FPG）、糖化血红蛋白(HbA1c)、空腹胰岛素（FINS）水平，计算稳态模型评估的胰岛素抵抗指数（HOMA-IR）及胰岛β细胞分泌功能指数（HOMA-β）。结果 （1）GDM组孕妇血清RBP4水平为（18.48±4.60）ng/ml,明显高于正常孕妇血清RBP4水平（13.26±2.35）ng/ml（P<0.01）。（2）GDM组孕妇FPG、HbA1c、FINS水平分别为（5.40±0.57）mmol/L、（5.68±0.58）%、（9.32±1.30）mmol/L，明显高于正常孕妇血清水平（4.99±0.27）mmol/L、（4.75±0.51）%、（8.24±0.77）mmol/L（P均<0.01）。（3）GDM组孕妇HOMA-IR为（2.24±0.43），明显高于正常孕妇（1.82±0.24）（P<0.01）；GDM组孕妇HOMA-β为（107.29±35.54），正常孕妇为（112.02±19.35）（P>0.05）。（4）Pearson相关分析结果显示，两组孕妇血清RBP4水平分别与HbA1c、FINS呈显著正相关性（r=0.400，0.266,P<0.05）；与HOMA-IR、HOMA-β无明显相关性（r=0.072，0.029，P>0.05）。结论 GDM孕妇血清RBP4水平明显升高，RBP4可能参与了GDM孕妇糖代谢紊乱，但是RBP4与GDM孕妇胰岛素抵抗无明显相关性；GDM孕妇尚不存在胰岛β细胞功能异常。 |
| 关键词: 视黄醇结合蛋白4（RBP4） 妊娠期糖尿病(GDM) 胰岛素抵抗 胰岛β细胞功能 |
| DOI：10.3969/j.issn.1674-3806.2011.05.04 |
| 分类号:R 587.1 |
| 基金项目:深圳市宝安区科技局资助项目（编号:2009373） |
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| The level and significance of serum retinol binding protein 4 in the pregnant women with gestational diabetes mellitus |
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REN Li-rong, YU Yan, HUANG Xiao-hong, et al.
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Department of Obstetrics,Baoan Maternal and Children Hospital, Shenzhen Guangdong 518133,China
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| Abstract: |
| ［Abstract］ Objective To explore the level and significance of serum retinol binding protein 4 (RBP4) in the pregnant women with gestational diabetes mellitus.Methods The levels of serum RBP4 in pregnant women with GDM (50 cases) and in normal pregnant women (50 cases) were tested individually by ELISA. Fasting plasma glucose （FPG）,glycosylated hemoglobin (HbA1c), fasting insulines (FINS), homeostasis modal assessment insulin resistance (HOMA-IR) and homeostasis modal assessment for beta cell function index (HOMA-β) were also tested.Results (1)The level of serum RBP4 in pregnant women with GDM (18.48±4.60)ng/ml was significantly higher than that in normal women (13.26±2.35)ng/ml (P<0.01).(2)The levels of FPG, HbA1c and FINS in pregnant women with GDM［(5.40±0.57)mmol/L;(5.68±0.58)%;(9.32±1.30）mmol/L］ were significantly higher than that in normal women［(4.99±0.27)mmol/L;(4.75±0.51)%；(8.24±0.77)mmol/L］(P<0.01). (3)The HOMA-IR of pregnant women with GDM (2.24±0.43) was significantly higher than that in normal women (1.82±0.24)(P<0.01). There was not significant difference between the two groups of pregnant women on HOMA-β［women with GDM: (107.29±35.54) VS normal women: (112.02±19.35) (P>0.05)］. (4)The results of Pearson correlation analysis showed that the level of serum RBP4 in two groups of pregnant women were positively correlative with the level of HbA1c and FINS significantly (r=0.400,0.266， P<0.05), while were not obviously correlative with the level of HOMA-IR and the HOMA-β in advanced stage of pregnancy (r=0.072, 0.029, P>0.05).Conclusion The level of serum RBP4 in pregnant women with GDM obviously increase. And the level of serum RBP4 may play a role in pregnant women with GDM,but there were no obvious correlation between the RBP4 and IR in these women;the abnormality of pancreatic islet beta cell function was not revealed yet in the GDM pregnant women. |
| Key words: Retinol binding protein 4（RBP4） Gestational diabetes mellitus(GDM) Insulin resistance Pancreatic islet beta cell function |
