| 摘要: |
| ［摘要］ 目的 探讨转录抑制因子ZHX2（zinc-fingers and homeoboxes 2,ZHX2）在肝细胞癌（hepatocellular carcinoma,HCC）中的表达及其与转移的关系。方法 通过RT-PCR方法，检测35例HCC癌组织及相应癌旁组织和8例正常肝组织中ZHX2 mRNA的表达，并分析其与临床病理参数的关系。结果 HCC癌组织中ZHX2 mRNA的表达率明显低于癌旁组织与正常肝组织(P<0.05)。术中发现伴随转移的HCC癌组织中ZHX2 mRNA的阳性表达率明显低于无转移的HCC（P<0.05）。ZHX2 mRNA的表达与血清甲胎蛋白（alpha-fetoprotein，AFP）水平呈负相关（P<0.05），而与年龄、性别、HBsAg感染、肿瘤直径、分化程度、是否伴随肝硬化无明显关系。结论 ZHX2低表达与HCC转移密切相关，并与AFP的高表达有关。 |
| 关键词: ZHX2 肝细胞癌（HCC） 转移 甲胎蛋白（AFP） |
| DOI：10.3969/j.issn.1674-3806.2011.05.05 |
| 分类号:R 735.7 |
| 基金项目:广西青年科学基金资助项目（编号：桂科青0728057） |
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| Experiment study of ZHX2 in HCC and it′s clinical significance |
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CHEN Wei-lu, LV Zi-li
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Department of Pathology, the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China
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| Abstract: |
| ［Abstract］ Objective To explore the expression of zinc-fingers and homeoboxes 2(ZHX2) in hepatocellular carcinoma(HCC) and their relationship with metastasis.Methods RT-PCR was used for detecting the ZHX2 mRNA of 35 HCC tumor tissues and adjacent-tumor liver tissues and 8 cases of normal liver tissues.The results were analyzed by combination with the clinical and pathological data of the patients.Results The positive rate of ZHX2 mRNA in tumor tissues was lower than those in adjacent-tumor liver tissues and normal liver tissues(P<0.05).The positive rate of ZHX2 mRNA in cases with preoperative metastsis was lower than that in cases of without metastsis(P<0.05).The expression of ZHX2 mRNA was correlated with the serum level of AFP(P<0.05),it was not correlated with age,sex,serum of HBsAg, tumor size,differentiation grade，liver cirrhosis.Conclusion Metastasis of HCC and high expression of AFP were related with low expression of ZHX2. |
| Key words: Zinc-fingers and homeoboxes 2 Hepatocellular carcinoma(HCC) Metastasis Alphafetoprotein(AFP) |
