| 摘要: |
| ［摘要］ 目的 探讨在不停用抗甲状腺药物（ATD）情况下使用131碘（131I）治疗格雷夫斯（Graves）病的临床疗效、适应证及价值。方法 将正在接受ATD治疗的75例Graves病患者，随机分为两组：观察组（28例）不停用ATD服131I治疗；对照组（47例）待停用ATD 2～4周后方服131I治疗。服131I 6个月后判定疗效。结果 观察组治愈率为17.9%，无效率为32.1%，好转率为35.7%；对照组治愈率为59.6%，无效率为10.6%，好转率为19.1%。两组疗效比较差异有统计学意义（P<0.05），两组毒副反应发生率比较差异无统计学意义（P>0.05）。结论 不停用ATD情况下使用131I治疗Graves病疗效欠佳，但能改善病情，为后期进一步治疗争取时机，可适用于重症且不宜停药的Graves病患者。 |
| 关键词: 不停药 抗甲状腺药物（ATD） 131碘 |
| DOI：10.3969/j.issn.1674-3806.2011.05.24 |
| 分类号:R 581.1 |
| 基金项目: |
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| Clinical research of therapeutic effect of 131I on Graves disease without withdrawal of anti-thyroid drug |
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TANG Zhen-wu,HUANG Jiang-he
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Department of Nuclear Medicine,the Second People′s Hospital of Qinzhou, Guangxi 535000,China
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| Abstract: |
| ［Abstract］ Objective To observe the theraperutic effect of 131Iodine (131I) on Graves disease without withdrawal of anti-thyroid drugs (ATD), and to determine the corresponding clinical efficacy, indications and value.Methods Seventy-five patients with Graves disease under the treatment of ATD were divided into two groups randomly, observation group (n=28) received 131I treatment without withdrawal of ATD; control group (n=47) received 131I treatment after 2 ～ 4 weeks of withdrawal of ATD.The therapeutic efficacy was determined at the end of six months after the treatment of 131I.Results In observation group the cure rate was 17.9%; inefficiency rate was 32.1%, improved rate was 35.7%. In control group the cure rate was 59.6%; inefficiency rate was 10.6%; improvement rate was 19.1%. The clinical efficiency in observation group was worse than the control group (P <0.05). The side effect rate showed no significant difference between the two groups (P>0.05). Conclusion Although the administration of 131I without withdrawal of ATD resulted in poor efficacy in the treatment of Graves disease, but this method still can alleviate the severity of Graves disease, which could provide the opportunity for further treatment.This method could be applied in severe cases which are not suitable for withdrawal of ATD. |
| Key words: Without withdrawal Anti-thyroid drugs (ATD) 131Iodine |
