| 摘要: |
| ［摘要］ 目的 探讨采用三维能量多普勒超声（3D-CPA）检测进行卵巢肿瘤的血管分型及定量分析血管指数（VI）与术后标本病理微血管密度（MVD）之间的关系。方法 采用3D-CPA检测116例卵巢实性或囊实性肿块的VI并进行血管分型，术后应用抗CD34单克隆抗体对病理切片进行免疫组织化学染色，计测肿瘤MVD，并进行VI与MVD相关性分析。结果 Ⅰ～Ⅳ型血流的VI及MVD值逐级增加，Ⅲ型及Ⅳ型血流的VI及MVD明显高于Ⅰ～Ⅱ型，恶性组的VI及MVD明显高于良性组（P<0.05）。VI与MVD之间呈正相关（r=0.83，P<0.01）。以VI≥0.04条/cm3诊断卵巢恶性肿瘤的敏感度为90.3%，特异度为82.2%。结论 3D-CPA计测VI值及血管分型与MVD具有密切相关性，能很好地反映卵巢肿瘤血管生成状况。3D-CPA是鉴别卵巢肿瘤良恶性的有效方法。 |
| 关键词: 三维能量多普勒 病理微血管密度 血管指数 |
| DOI：10.3969/j.issn.1674-3806.2012.02.02 |
| 分类号:R 711 |
| 基金项目:广西自然科学基金资助项目（编号：2010GXNSFB013079）；广西卫生厅科研课题（编号：桂卫Z2008080） |
|
| Research of correlation between the vessels index detected by three-dimensional color power angiography and pathological microvessel density in ovarian tumors |
|
ZHENG Hong-yu,SHEN Gui-xin,KANG Li-ke,et al.
|
|
Department of Ultrasound,the People′s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China
|
| Abstract: |
| ［Abstract］ Objective To investigate the correlation between the type of vessels and quantitative analysis vessels index (VI) detected by 3D-CPA and microvessel density (MVD) by pathological specimens after operation in ovarian tumour.Methods The vessels index(VI) and the type of vessels were detected by 3D-CPA in 116 patients who had ovarian tumour. After operation the pathological specimens were examined by immunohistochemical staining to detect MVD by applicating single anti-CD34 clone antibodies.The relevant analysis were made to definite the correlation between VI and pathological MVD.Results The VI and MVD of Ⅰ～Ⅳ type vessels increased gradually.The VI and MVD of Ⅲ and Ⅳ type vessels were significantly higher than those of Ⅰ～Ⅱ type vessels,and the VI and MVD in malignant tumour groups were significantly highter thanthose in benign tumour groups（P<0.05）.There was positive correlation between VI and MVD （r=0.83，P<0.01）.When the VI≥0.04 /cm3 served as diagnostic criteria of ovarian malignant tumour,sensitivity and specificity were 90.3%,82.2% respectively.Conclusion The vessels index(VI) and the type of vessels detected by 3D-CPA were closely correlated with MVD. 3D-CPA can well reflect generating conditions of the ovarian tumour vessels.It was an effective way to identify benign or malignant of ovarian tumour. |
| Key words: Three-dimensional power doppler Pathological microvessel density Vessels index |
