| 摘要: |
| ［摘要］ 目的 探讨丹红注射液对慢性肺源性心脏病急性加重期的临床疗效及对C反应蛋白、血液流变学的影响。方法 将80例慢性肺源性心脏病急性加重期患者随机分为治疗组和对照组，两组均采用吸氧、抗炎、强心利尿、扩血管、纠正酸碱失衡及水电解质紊乱等常规治疗,治疗组同时加用丹红注射液，1次/d，14 d为一疗程。治疗前、治疗14 d后，分别行血C反应蛋白、血液流变学（D-二聚体、血红蛋白、纤维蛋白原含量及血细胞比容）检查。结果 治疗14 d后，治疗组疗效优于对照组(P<0.05)，两组患者C反应蛋白、血液流变学(D-二聚体、血红蛋白、血细胞比容及纤维蛋白原)含量均降低，与治疗前比较差异均有统计学意义(P<0.05)，但治疗组下降幅度大于对照组(P<0.05)。结论 丹红注射液可明显降低慢性肺源性心脏病急性加重期患者C反应蛋白、血液流变学水平，对提高疗效、改善高凝状态有重要意义。 |
| 关键词: 丹红注射液 慢性肺源性心脏病 C反应蛋白 血液流变学 |
| DOI：10.3969/j.issn.1674-3806.2012.02.06 |
| 分类号:R 541.5 |
| 基金项目: |
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| The therapeutic effects of danhong injection and its influence on the concentration level of c-reactive protein and hemorheology in patients with acute exacerbation of chronic cor pulmonale |
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WANG Hua,HUANG Ling,CHEN Ping,et al.
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Department of Integrated TCM and Western Medicine,the People′s Hospital of Lianjiang,Guangdong 524400,China
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| Abstract: |
| ［Abstract］ Objective To explore the therapeutic effects of danhong injection and its influence on the concentration level of c-reactive protein and hemorheology in patients with acute exacerbation of chronic cor pulmonale.Methods Eighty patients with acute exacerbation of chronic cor pulmonale were randomly divided into the treatment group and the control group. Both groups were treated by using of oxygen, anti-inflammatory, cardiac diuretic, vasodilatation, correcting acid-base balance and electrolyte imbalance. At the same time, the treatment group was added danhong injection, once a day, for 14 days. The levels of c-reactive protein, hemorheology (D-dimer, hemoglobin, fibrinogen, hematocrit value) were determined before the entry into the trial and after 14 days of the trial, respectively.Results After 14 days, the therapeutic effects of treatment group was better than that of control group (P<0.05). The concentration level of c-reactive protein and hemorheology(D-dimer,hemoglobin,fibrinogen,hematocrit value) were significantly lower in both groups (P<0. 05).However, the concentration level of c-reactive protein and hemorheology in treatment group were significantly lower than that in control group (P<0.05).Conclusion Danhong injection can reduce the concentration level of the c-reactive protein and hemorheology significantly and plays an important role in increasing therapeutic effect and improving hypercoagulable state in patients with acute exacerbation of chronic cor pulmonale. |
| Key words: Danhong injection Chronic cor pulmonale C-reactive protein Hemorheology |
