| 摘要: |
| ［摘要］ 目的 探讨白细胞介素6（IL-6）和C反应蛋白（CRP）在小儿支原体肺炎（MPP）的发生、发展中的重要作用，以判断病情的严重程度及预后。方法 47例已确诊为MPP的急性期患儿,根据心肌酶谱的测定结果，分为心肌损伤组28例和无心肌损伤组19例，另选28名健康儿童为对照组。分别采集空腹静脉血,用ELISA方法测定血清IL-6,透射比浊法测定CRP的水平。结果 肺炎支原体感染组血清IL-6和CRP较对照组升高,差异有统计学意义(P<0.01)，并且心肌损伤组显著高于无心肌损伤组(P<0.01)，血清IL-6与CRP水平呈中度正相关（r=0.690,P<0.001）。结论 肺炎支原体（MP）感染患儿急性期IL-6和CRP明显升高，且二者成正相关，合并心肌损伤者高于无心肌损伤者，提示其水平变化程度可能与病情轻重相关。 |
| 关键词: 支原体肺炎 白细胞介素6 C反应蛋白 急性期 儿童 |
| DOI：10.3969/j.issn.1674-3806.2012.02.07 |
| 分类号:R 392.7 |
| 基金项目: |
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| Analysis of the changes of serum levels of interleukin-6 and C reaction protein in 47 children with mycoplasma pneumoniae pneumonia at acute stage |
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CHEN Yun-zhi,TIAN Dong
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Department of Clinical Laboratory,the Chengwu County People′s Hospital,Shandong 274200,China
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| Abstract: |
| ［Abstract］ Objective To explore the important role of interleukin-6 (IL-6) and C reaction protein (CRP) in onset and development of mycoplasma pneumonine pneumonia (MPP) and judge the severity and prognosis by studying the changes of IL-6 and CRP in peripheral blood of children with MPP at acute stage.Methods Forty-seven children with MPP were divided into myocardial injury group and non-myocardial injury group according to myocardial enzymogram. The serum levels of IL-6 with the method of enzyme-linked immunosorbent assay (ELISA) and CRP with turbidimetric assay in automatic biochemical analyzer were determined in those patiets as well as 28 controls.Results The levels of serum IL-6 and CRP in children with MPP were higher than those in the controls (P<0.01). The levels of serum IL-6 and CRP in the myocardial injury group were higher than those in the non-myocardial injury group (P<0.01). The level of serum IL-6 was positively correlated with the level of serum CRP （r=0.690,P<0.001）.Conclusion The concertration of IL-6 and CRP in children with MPP at acute stage increased significantly and there were significant positive correlation between them, indicating acute phase of MPP in children associated with a clear inflammatory response. Furthermore the levels of IL-6 and CRP in children with myocardial injury were higher than those without myocardial injury, suggesting that the changes of levels of IL-6 and CRP may be associated with disease severity. |
| Key words: Mycoplasma pneumoniae pneumonia IL-6 CRP Acutestage Children |
