| 摘要: |
| ［摘要］ 芒果甙是一种黄酮类化合物，具有多种生理和药理作用，近期的研究报道芒果甙具有抗肿瘤作用。芒果甙抗肿瘤作用主要包括抑制肿瘤细胞增殖生长、阻断细胞周期、诱导细胞凋亡、抑制NF-κB信号途径激活、影响E-cad介导的细胞黏附及信号转导、干预线粒体通透性转换及与化疗药物发挥联合作用等。 |
| 关键词: 芒果甙 抗肿瘤机制 |
| DOI：10.3969/j.issn.1674-3806.2012.10.32 |
| 分类号:R 73 |
| 基金项目:广西自然科学基金资助项目(编号：桂科青0447018) |
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| Research progress on mangiferin anti-tumor mechanism |
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LIU Xiao-chun, JIAO Wei
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Guangxi Center for Clinical Laboratory,the People′s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China
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| Abstract: |
| ［Abstract］ Mangiferin is a flavonoid compound and has a variety of physiological and pharmacological effects. Recent studies have reported that mangiferin has anti-tumor effect. Mangiferin anti-tumor mechanism includes inhibition of tumor cell proliferation and growth, blocking the cell cycle, induction of apoptosis, inhibition of NF-κB signaling pathway activation, interference in E-cadherin-mediated cell adhesion and signal transduction, intervention of mitochondrial permeability transition and the combined effects of chemotherapy drugs. |
| Key words: Mangiferin Anti-tumor mechanism |
