| 摘要: |
| ［摘要］ 目的 探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）并冠状动脉粥样硬化性心脏病(简称冠心病)的血管内皮功能受损情况。方法 选取2009-07～2013-02于我院就诊的184例患者，常规记录患者一般资料，行多导睡眠监测和冠状动脉造影。冠状动脉造影前采集空腹静脉血，采用酶联免疫吸附法(ELISA)测定血浆血栓调节蛋白(TM)。结果 根据多导睡眠图和冠状动脉造影结果，184例患者分为对照组、冠心病组、OSAHS组及OSAHS并冠心病组。各组在年龄、性别构成及体重指数(BMI)方面差异无统计学意义（P均>0.05）。对照组、冠心病组、OSAHS组、OSAHS并冠心病组血清TM水平（OD值）分别为（2.91±1.81）、（20.45±35.57）、（21.93±44.32）、（42.13±59.82）（P均<0.05）；对照组低于其他三组，OSAHS并冠心病组高于其他三组（P均<0.05）,但冠心病组与OSAHS组差异无统计学意义。结论 OSAHS并冠心病患者存在更为广泛、更为严重的内皮功能受损，OSAHS是冠心病的危险因素之一。 |
| 关键词: 阻塞性睡眠呼吸暂停低通气综合征 冠心病 血浆TM 血管内皮 |
| DOI：10.3969/j.issn.1674-3806.2013.04.03 |
| 分类号:R 563.8 |
| 基金项目:广西自然科学基金资助项目(编号：桂科自0991217) |
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| Measurement of plasma soluble thrombomodulin in obstructive sleep apnea-hypopnea syndrome patients with coronary heart disease |
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YUAN Jun, JIANG Li-jun,LIN Ying-zhong,et al.
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Department of Cardiovascular Disease,the People’s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China
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| Abstract: |
| ［Abstract］ Objective To Explore the endothelial function in obstructive sleep apnea hypopnea syndrome (OSAHS) patients with coronary atherosclerotic artery disease (CHD).Methods One hundred and eighty-four subjects were recruited in our hospital from July 2009 to February 2013, recorded the gender, age, height, weight, etc,and all subjects attended sleep-laboratory polysomnography and coronary angiography.Fasting venous blood before coronary angiography was collected,and the level of plasma thrombomodulin(TM) was detected by the enzyme-linked immunosorbent assay(ELISA).Results According to the results of polysomnography and coronary angiography, 184 patients were divided into control group, CHD group, OSAHS group, and OSAHS-CHD group. There were no significant difference among the four groups in age, sex, and body mass index (BMI). In plasma TM level, the control group were lower than CHD group,OSAHS group,and OSAHS-CHD group (2.91±1.81 VS 20.45±35.57,2.91±1.81 VS 21.93±44.32,2.91±1.81 VS 42.13±59.82,P all <0.05); OSAHS-CHD group was significantly higher than the control group, CHD group, OSAHS group(42.13±59.82 VS 2.91±1.81, 42.13±59.82 VS 20.45±35.57,42.13±59.82 VS 21.93±44.32，P<0.05), but no significant difference between CHD group and OSAHS group （20.45±35.57 VS 21.93±44.32，P>0.05）.Conclusion Patients with OSAHS and CHD have a serious vascular endothelial function disorder, OSAHS is one of the risk factors for coronary heart disease. |
| Key words: Obstructive sleep apnea-hypopnea syndrome(OSAHS) Coronary heart disease Plasma thrombomodulin Vascular endothelium |
