| 摘要: |
| ［摘要］ 目的 通过研究多囊卵巢综合征（PCOS）患者治疗前后血清sICAM-1水平变化及其与代谢各指标、性激素等的相关性，探讨血清sICAM-1水平在PCOS中的作用。方法 随机选取PCOS患者31例，测定体重指数、腰臀比、血清sICAM-1、性激素、血脂、空腹血糖、空腹胰岛素等，予达英-35治疗3个月经周期后，重复上述各项指标测定。结果 （1）PCOS患者血清sICAM-1水平通过达英-35治疗后明显下降（P<0.01）；（2）达英-35治疗后血清卵泡刺激素（FSH）、黄体生成素（LH）、睾酮（T）及毛发评分降低（P<0.05），高密度脂蛋白（HDL）、载脂蛋白A（apoA）、载脂蛋白A1/B（apoA1/B）、催乳素（PRL）、体重指数（BMI）明显增高（P<0.01）；（3）PCOS患者血清sICAM-1水平与BMI、总胆固醇（TG）、低密度脂蛋白（LDL）、载脂蛋白B（apoB）呈正相关（P<0.05）,与HDL呈负相关（P<0.05）。结论 sICAM-1水平与脂代谢指标密切相关，达英-35能明显改善PCOS患者临床症状，并能降低血清sICAM-1水平。 |
| 关键词: 多囊卵巢综合征 可溶性细胞间粘附分子-1 达英-35 |
| DOI：10.3969/j.issn.1674-3806.2013.04.04 |
| 分类号:R 711 |
| 基金项目:广西研究生创新项目（编号：2010105981002M234）；广西壮族自治区人口和计划生育委员会科研课题（编号：桂人口计生研1103） |
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| Expression of serum soluable intercellur adhension molecule-1 in patients with polycystic ovarian syndrome |
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XIAO Li, JIANG Feng-yan, QIN Yu-qin, et al.
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Department of Obstetrics and Gynecology，the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To study the change of levels of sICAM-1 and its relation with metabolic indicators, sex hormones in patients with PCOS, in order to explore the role of sICAM-1 levels in PCOS.Methods Thirty-one patients with PCOS were selected randomly. Body mass index, waist-to-hip ratio, serum of sICAM- 1, sex hormones, lipids, fasting glucose, fasting insulin were detected before and after Diane-35 treatment of three cycles.Results （1）Serum sICAM-1 was significantly decreased after treatment（P<0.01）.（2）FSH,LH,T, hair score were significantly decreased after treatment,while HDL,apoA,apoA1/B,PRL,Body mass index were significantly increased.（3） Levels of sICAM-1 in women with PCOS were correlated positively with BMI,TG,LDL,apoB, but correlated negatively with HDL.Conclusion Serum sICAM-1is closely related with PCOS. Diane-35 could significantly improve the clinical symptoms of PCOS patients, and can reduce serum sICAM-1 levels. |
| Key words: Polycystic ovarian syndrome(PCOS) sICAM-1 Diane-35 |
