| 摘要: |
| ［摘要］ 目的 检测转化生长因子-β1（TGF-β1）在人和小鼠正常口腔黏膜、异常增生及鳞癌组织中的表达情况，探讨其在口腔癌发生与发展中的意义。方法 采用免疫组织化学技术，分别检测人和小鼠正常口腔黏膜、中重度异常增生、高分化鳞癌组织各12例中TGF-β1的表达情况，并对人和小鼠各型组织中TGF-β1的表达进行分析。结果 正常口腔黏膜组中人和小鼠TGF-β1表达率分别为33.3%（4/12）和41.7%（5/12）；口腔异常增生组中人和小鼠TGF-β1表达率分别为50.0%（6/12）和58.3%（7/12）；口腔鳞癌组中人和小鼠TGF-β1表达率均为75.0%（9/12）。结论 随着组织恶性程度的升高，人和小鼠各型组织中TGF-β1的阳性表达率逐渐增加，表达部位与强度具有相似性，表明TGF-β1是参与肿瘤发生与发展过程中的一个重要因子，并且人与小鼠口腔癌的发展过程具有相似性。 |
| 关键词: 转化生长因子-β1 人 小鼠 口腔鳞癌 免疫组化 |
| DOI：10.3969/j.issn.1674-3806.2013.04.06 |
| 分类号:R 739.8 |
| 基金项目:广西卫生厅重点科研课题（编号：桂卫重2010081） |
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| Expression of TGF-β1 in oral squamous cell carcinoma of human and mouse |
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WEI Bao-sheng, YU Da-hai，LI Ming-wu,et al.
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Department of Oral and Maxillofacial Surgery，College of Stomatology，Guangxi Medical University，Nanning 530021，China
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| Abstract: |
| ［Abstract］ Objective To detect the expression of TGF-β1 in oral squamous cell carcinoma(OSCC) of human and mouse so as to investigate their role in the development of oral carcinoma.Methods Immunohistochemical method was used to detect and analyse the expression of TGF-β1 gene in 12 cases of normal oral mucosa, 12 cases of oral dysplasia and 12 cases of oral squamous cell carcinoma in human and mouse, respectively.Results In the group of normal oral mucosa of human and mouse, the positive TGF-β1 protein expression rates were 33.3%, 41.7 %, respectively; and in the group of oral dysplasia, the rates were 50.0%, 58.3 %, respectively; while in the group of OSCC, the rates were all 75.0%.Conclusion As the degree of malignancy increased, the expression of TGF-β1 protein of human and mouse increased gradually and there was the similar expression of position and intensity. This suggests that TGF-β1 plays an essential role in tumor progression and the development of OSCC of the human and mouse may be similar to each other. |
| Key words: TGF-β1 Human Mouse Oral squamous cell carcinoma Immunhistochamistry |
