| 摘要: |
| ［摘要］ 目的 探讨初发2型糖尿病（T2DM）患者血胰高血糖素样肽-1（GLP-1）对胰高血糖素及早相胰岛素分泌的影响。方法 以新发T2DM患者(T2DM组)、健康体检者（对照组）为研究对象，采用标准馒头餐试验，观察空腹、进餐后30 min、120 min静脉血浆GLP-1动态变化及对血浆葡萄糖、胰高血糖素、胰岛素分泌的影响。结果 初发T2DM组患者馒头餐各时点GLP-1水平均分别较对照组显著降低，差异有统计学意义(P<0.05)，馒头餐后30 min、120 min胰岛素水平显著降低(P<0.05)，但空腹胰岛素无明显差异(P>0.05)；而胰高血糖素则较对照组各时点显著升高，差异有统计学意义(P<0.05)。初发T2DM组早相胰岛素分泌指数(ΔFINS30/ΔG30)显著低于对照组,差异有统计学意义(P<0.05)。结论 初发T2DM患者存在GLP-1分泌减少，GLP-1缺乏可能是T2DM患者胰岛β细胞分泌缺乏及胰高血糖素分泌过多的重要因素。 |
| 关键词: 2型糖尿病 胰高血糖素样肽-1 胰高血糖素 胰岛素分泌指数 |
| DOI：10.3969/j.issn.1674-3806.2013.08.03 |
| 分类号:R 587.1 |
| 基金项目:广东省科技计划资助项目（编号：2011B031800231）；广东省医学科研基金资助项目（编号：B2011243） |
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| Effects of the change of GLP-1 level on glucagon and early phase insulin secretion in the patients with the newly diagnosed type 2 diabetes |
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WU Mei-fen, WU Ge, Cai Xiao-ling,et al.
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Department of Endocrine,the Affiliated Hospital of Guangdong Medical College,Zhanjiang 524001,China
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| Abstract: |
| ［Abstract］ Objective To explore the effects of the change of Glucagon-like peptide-1 level on glucagon and early phase insulin secretion in the patients with the newly diagnosed type 2 diabetes.Methods Patients with the newly diagnosed type 2 diabetes(T2DM group) and healthy volunteers(control group) were used as the research object, and the standardized bread meal test was used to observe effects of the dynamic changes of GLP-1 level at 0 min, 30 min and 120 min on plasma glucose, glucagon and insulin secretion.Results The levels of GLP-1 at each time point in newly diagnosed T2DM group were significantly reduced compared with those of the control group respectively(P<0.05); The levels of insulin at 30 min and 120 min were both significantly reduced compared with those of the control group respectively (P<0.05),but the difference had no statistical significance at 0 min between two groups(P>0.05);The levels of glucagon at each time point in newly diagnosed T2DM group were significantly higher than that of the control group(P<0.05). The first-phase insulin secretion index of newly diagnosed T2DM group was significantly reduced compared with those of the control group(P<0.05).Conclusion The levels of GLP-1 at each time point in newly diagnosed patients with type 2 diabetes mellitus were significantly reduced;GLP-1 dificiency might be the important factors of lack of islet beta cell secretion and insrease of glucagon secretion. |
| Key words: Type 2 diabetes mellitus Glucagon-like peptide-1（GLP-1） Glucagon Insulin secretion index |
