DNA修复基因XRCC1 Arg194Trp Arg280His和Arg399Gln多态性与前列腺癌相关性的Meta分析

刘　斐; 张海峰; 焦　伟; 蓝　娇; 肖瑞平; 刘　刚

引用本文:	刘　斐，张海峰，焦　伟，蓝　娇，肖瑞平，刘　刚.DNA修复基因XRCC1 Arg194Trp Arg280His和Arg399Gln多态性与前列腺癌相关性的Meta分析[J].中国临床新医学,2013,6(8):757-762.

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DNA修复基因XRCC1 Arg194Trp Arg280His和Arg399Gln多态性与前列腺癌相关性的Meta分析
刘　斐，张海峰，焦　伟，蓝　娇，肖瑞平，刘　刚
530021　南宁，广西壮族自治区人民医院科研实验中心（刘　斐，焦　伟，蓝　娇，肖瑞平），泌尿外科（刘　刚）；510120　广州，中山大学孙逸仙纪念医院心血管内科（张海峰）

摘要:

［摘要］　目的　探讨DNA修复基因X线修复交叉互补因子1（XRCC1）主要单核苷酸多态性与前列腺癌易感性的关系。方法　在MEDLINE、EMBASE和OVID数据库上检索文献，收集及提取符合纳入标准的以XRCC1密码子194、280、399多态性与前列腺癌易感性为内容的病例对照研究文献，应用Stata统计软件进行Meta分析，比值比（ORs）及其95%可信区间（95%CI）评价关联强度；应用SPSS软件分析吸烟与前列腺癌关系，OR评价其相对危险度。结果　XRCC1 399 Gln/Gln和XRCC1 280 Arg/His与前列腺癌的发病风险有关（Gln/Gln vs Arg/Arg：OR=1.27，95%CI=1.02～1.59；Arg/His vs Arg/Arg：OR=1.66，95%CI=1.09～2.52），尤其在亚组分析中亚洲人的Gln/Gln明显增加了前列腺癌的发病风险（OR=1.52，95%CI=1.18～1.96）；Arg194Trp与前列腺癌的发病风险无明显关联。吸烟是前列腺癌的危险因素（χ²=13.974，P=0.000，OR=1.22）。结论　XRCC1 399 Gln/Gln和280 Arg/His可能与前列腺癌的易感性相关。

关键词: 前列腺癌 X线修复交叉互补因子1 基因多态性 Meta分析

DOI：10.3969/j.issn.1674-3806.2013.08.10

分类号:R 737

基金项目:

XRCC1 Arg194Trp, Arg280His, Arg399Gln polymorphisms and prostate cancer risk: a Meta-analysis

LIU Fei,ZHANG Hai-feng,JIAO Wei,et al.

Research Center of Medical Science, the People′s Hospital of Guangxi Zhuang Autonmous Region, Nanning 530021, China

Abstract:

［Abstract］　Objective　To evaluation the relationship between X-ray repair cross-complementing group 1 (XRCC1) single nucleotide polymorphisms （SNPs） and genetic susceptibility to prostate cancer (Pca) risk.Methods　We searched on MEDLINE, EMBASE and OVID, collected and abstracted the case-control studies about XRCC1 codon 194, 280, 399 polymorphisms and genetic susceptibility of Pca; did Meta-analysis by Stata, Odds ratios (ORs) and 95% confidence interval (95%CI) were calculated to evaluate correlation strength; the relation between smoking and Pca was analyzed by SPSS, OR evaluated relative risk of smoking.Results　XRCC1 399 Gln/Gln and XRCC1 280 Arg/His were related with risk for Pca (Gln/Gln vs Arg/Arg: OR=1.27, 95%CI=1.02～1.59; Arg/His vs Arg/Arg:OR=1.66, 95%CI=1.09～2.52), especially Asian Gln/Gln obviously increased risk for Pca (OR=1.52, 95%CI=1.18～1.96); Arg194Trp was not related with risk for Pca. Smoking was a risk factor of Pca (χ²=13.974, P=0.000, OR=1.22).Conclusion　XRCC1 399 Gln/Gln and XRCC1 280 Arg/His were probably related with genetic susceptibility to Pca.

Key words: Prostate cancer X-ray repair cross-complementing group 1 Genetic polymorphisms Meta-analysis