| 摘要: |
| ［摘要］ 目的 探讨桉柠蒎肠溶软胶囊联合丙酸氟替卡松鼻喷剂预防放射性鼻窦炎（RNS）的效果。方法 将2009-03～2011-03该院耳鼻咽喉头颈肿瘤科收治的首诊鼻咽癌患者60例，随机分为治疗组和对照组各30例。治疗组采用常规放化疗联合丙酸氟替卡松鼻喷剂喷鼻及口服桉柠蒎肠溶软胶囊治疗，对照组采用常规放化疗治疗。比较两组放疗后6个月RNS的发生率。结果 放疗后6个月治疗组RNS的发生率为40.0%，对照组为76.7%，治疗组发生率低于对照组（P<0.01）。分型分期：治疗组Ⅰ型1期及Ⅰ型2期均为41.67%，Ⅰ型3期为16.67%；对照组Ⅰ型1期为8.70%，Ⅰ型2期为56.52%，Ⅰ型3期为34.78%。两组比较差异有统计学意义（P<0.05）。结论 桉柠蒎肠溶软胶囊联合丙酸氟替卡松鼻喷剂预防RNS发生有一定的临床疗效，且方法简便。 |
| 关键词: 鼻咽癌 放疗 鼻窦炎 |
| DOI：10.3969/j.issn.1674-3806.2013.08.13 |
| 分类号:R 76 |
| 基金项目: |
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| The effect of combination of fluticasone propionate nasal spray and eucalyptol-linonene-pinene enteric soft capsule in the prevention of radioactive sinusitis |
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HUANG Bo, LAN Gui-ping, WENG Jing-jin, et al.
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Department of Otolaryngology Head and Neck Oncology，the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021，China
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| Abstract: |
| ［Abstract］ Objective To perspectively observe the effect of combination of fluticasone propionate(FP) nasal spray and eucalyptol-linonene-pinene enteric soft capsule(ELP) in the prevention of radioactive sinusitis in nasopharyngeal carcinoma(NPC) patients.Methods Sixty NPC patients were divided into two groups by matched pair design from March 2009 to March 2011 in our department.Patients of the treating group received conventional radiotherapy（RT）, chemotherapy（CT）, FP nasal spray oral ELP.In control group,the patients received CT and RT alone. Six months after treatment the sinusitis was measured by using CT and MRI for the two groups.Results Following up for six months,the detected rates of sinusitis in the treating group was 40.0% and 76.7% in the control group, there were significantly difference between the two groups (P<0.01).The type and stage sinusitis: type 1,stage1 and type 1,stage2 accounted 41.67% respectively, type 1,stage3, 16.67% in the treating group;and 8.70%,56.52%,34.78% respectively in the control group.There were statistically significant difference between two groups(P<0.05).Conclusion Combination of FP nasal spray and ELP can reduce the incidence of radioactive sinusitis and it is easy of use. |
| Key words: Nasopharyngeal carcinoma Radiotherapy Sinusitis |
