| 摘要: |
| ［摘要］ 目的 探讨糖尿病靶器官损害中的主要影响因素。方法 检测糖尿病靶器官损害患者（ODM组）56例和无糖尿病靶器官损害患者（DM组）40例。采用全自动化学免疫发光法检测尿微量蛋白，计算尿白蛋白排泄率（UAER），采用全自动血凝仪测定D-二聚体（D-Dimer,D-D），采用散射比浊法检测血清超敏C反应蛋白（hs-CRP）水平。应用彩色多普勒检测心脏及颈总动脉，测量颈总动脉内-中膜厚度（IMT）和左室重量指数（LVMI）。以检查结果异常作为判断糖尿病靶器官损害的指标并比较两组性别、年龄、病程、糖化血红蛋白（HbA1c）、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高血压。结果 病程、年龄、HbA1c、TC、TG、LDL-C、高血压、UAER、hs-CRP、D-D在糖尿病靶器官损害患者中指标增高，与DM组比较差异有统计学意义（P<0.01）。经多因素Logistic逐步回归分析显示，LDL-C、hs-CRP对糖尿病靶器官的损害有明显影响(P<0.05)。结论 LDL-C、hs-CRP与糖尿病靶器官损害的发生、发展密切相关，可作为判断糖尿病预后及治疗效果的参考指标。 |
| 关键词: 糖尿病 靶器官 高血压 低密度脂蛋白胆固醇 高敏C反应蛋白 D-二聚体 |
| DOI：10.3969/j.issn.1674-3806.2013.11.11 |
| 分类号:R 587.1 |
| 基金项目: |
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| Correlation study of target organ damage in diabetes patients |
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LI Ni, ZHONG Mei, LIAO Ke-hua, et al.
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Department of Endocrinology,the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021,China
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| Abstract: |
| ［Abstract］ Objective To explore the main influence factors of the target organ damage in the diabetes patients.Methods Fifty-six diabetes patients with target organ damage(ODM group) and 40 diabetes patients without with target organ damage(DM group) were detected.The urine micro protein was tested with automatic chemical immune luminescence method and the albumin excretion rate(UAER) was calculated. D-D was detected with fully automatic blood coagulation analyzer and serum hs-CRP levels with scattering turbidimetric method. Color doppler ultrasound was used for detecting common carotid artery intima-media thickness(IMT) and left ventricular mass index(LVMI). The detected abnormal results were used as indexes of target organ damage in the diabetes patients and the two groups were compared of gender, age, course, glycosylated hemoglobin(HbA1c), total cholesterol(TC), triglycerides(TG), low density lipoprotein cholesterol(LDL-C), hypertension.Results Course,age, HbA1c,TC,TG, LDL-C, hypertension, UAER, hs -CRP, D-D were increased in ODM group, compared with DM group ,the difference between two group were statistically significant(P<0.01). The multi-factor Logistic stepwise regression analysis showed that LDL-C、hs-CRP had significant effect on the target organ damage in diabetes patients(P<0.05).Conclusion LDL-C,hs-CRP are closely related to the occurrence and development of target organ damage in diabetes patients, and can be used as reference indexes for evaluating prognosis and therapeutic effect of diabetes. |
| Key words: Diabetes Target organ Hypertension LDL-C High-sensitivity c-reactive protein D-dimer |
