| 摘要: |
| ［摘要］ 目的 探讨肿瘤坏死因子α（TNF-α）、白介素-1β（IL-1β）、血清骨保护素（OPG）与2型糖尿病合并冠心病的关系。方法 入选健康个体（对照组）和2型糖尿病合并冠心病患者（冠心病组）各30例，用ELISA方法测定TNF-α、IL-1β、OPG，生化法测定血糖及糖化血红蛋白，并观察组间各指标的变化及相互关系。结果 2型糖尿病合并冠心病组血清空腹血糖、糖化血红蛋白、OPG明显高于对照组（P均<0.01）,TNF-α、IL-1β高于对照组(P均<0.05)。Spearman相关分析显示，OPG与TNF-α、IL-1β呈显著正相关（P均<0.01）。结论 血糖、糖化血红蛋白、TNF-α、IL-1β、OPG在2型糖尿病合并冠心病患者中明显增高，OPG与TNF-α、IL-1β改变有关。 |
| 关键词: 2型糖尿病 冠心病 肿瘤坏死因子α 白介素-1β 骨保护素 |
| DOI：10.3969/j.issn.1674-3806.2014.02.04 |
| 分类号:R 58 |
| 基金项目:广西自然科学基金资助项目(编号：桂科回0832018) |
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| Study on the relationship between serum TNF-α,IL-1β, Osteoprotegerin and type 2 diabetes mellitus with coronary artery disease |
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LU Wei-jun，CHEN Hui, LIU Ling，et al.
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Department of Cardiovascular Thoracic Surgery，the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To investigate the relationship between tumor necrosis factor-α（TNF-α）,Interleukin-1β（IL-1β）,Osteoprotegerin（OPG）and type 2 diabetes mellitus（T2DM） with coronary artery disease(CAD).Methods Thirty healthy individuals（control group）, and 30 T2DM patients with CAD(T2DM+CAD) group were selected. ELISA was used for determination of TNF-α，IL-1β and OPG，biochemistry method for blood glucose and glycosylated hemoglobin, and the data in all groups and the relationship between the factors was observed.Results Fasting blood-glucose, glycosylated hemoglobin， OPG in T2DM group were obviously higher than those in control group（P<0.01）,and TNF-α,IL-1β in T2DM group were obviously higher than those in control group（P<0.05）.Spearman correlation analysis showed that the positive correlation existed between OPG and TNF-α,IL-1β(P<0.01）.Conclusion The levels of blood glucose，glycosylated hemoglobin，TNF-α,IL-1β and OPG in T2MD group increase obviously. The level of OPG was related to the changes of TNF-α and IL-1β. |
| Key words: Type 2 Diabetes mellitus（T2DM） Coronary artery disease Tumor necrosis factor-α Interleukin-1β Osteoprotegerin |
