| 摘要: |
| ［摘要］ 目的 了解该院2012年药物变态反应（DA）的发病及诊治情况。方法 对该院2012年发生的147例DA进行回顾性分析。结果 全身性反应79例（53.7%），其中过敏性休克6例；皮肤反应68例（46.3%）。导致DA的药物前三位是抗生素、中药注射剂、抗肿瘤药物。静脉给药途径发生率最高，发生快，症状重，口服及局部外用药发生率较低，发生慢，症状轻。经停药（或换药）、抗过敏、对症、激素治疗均缓解或好转，6例过敏性休克均治愈。结论 应加强抗生素、中药注射剂、抗肿瘤药物等新药、中药的管理，密切关注患者的用药经过，及时发现DA及处理，确保患者用药安全。 |
| 关键词: 药物变态反应 临床表现 诊断 治疗 |
| DOI：10.3969/j.issn.1674-3806.2014.03.13 |
| 分类号:R 969 |
| 基金项目: |
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| Analysis of 147 cases of drug allergy in our hospital in 2012 |
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WU Wei
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Department of Pharmacy, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To investigate the incidence and treatment of drug alletgy(DA) in our hospital in 2012.Methods One hundred and forty-seven cases of DA in our hospital during 2012 were retrospectively analyzed.Results There were 79 cases of systemic reaction(53.7%) including 6 cases of allergic shock, 68 cases of skin reaction(46.3%). The fist three drugs resulting in DA included antibiotics, antineoplastic drugs and traditional Chinese medicine injection.The DA was characterized by acute onset and severe symptoms;The DA incidence of intravenous medication was the highest. The DA incidence of oral and topical medication was lower,the DA was characterized by slower onset and milder symptoms. By stopping(or changing) drugs. anti-allergic therapy hormone, symptomatic treatment, the symptoms can be alleviated or disease condition got better; 6 cases of allergic shock also were cured.Conclusion It is necessary to strengthen the management of traditional Chinese medicine injection agent, antibiotiotis and antineoplastic drugs, pay close attention to the medication process of patients, timely detect and treat DA,in order to ensure the safety of patients in medication process. |
| Key words: Drug allergy(DA) Clinical manifestation Diagnosis Treatment |
