| 摘要: |
| ［摘要］ MicroRNA（miRNA）是一类内源性高度保守的单链小分子非编码RNA，长度约18～22个核苷酸（nt），具有组织特异性和时序特异性，在转录后水平调控靶基因的翻译或表达。miRNA在细胞生长、增殖、代谢、凋亡等生物学过程中发挥重要作用。研究表明，miRNA与支气管哮喘(哮喘)的发生发展存在密切关系，现已发现，若干miRNA，如Let-7家族、miR-125家族、miR-26家族、miR-155、miR-21、miR-133a、miR-26a、miR-221等的异常表达与哮喘相关。该文综述miRNA在哮喘的病理生理学基础及其以持续气道炎症、气道高反应性和气道重塑为特征的发病机制中的作用。 |
| 关键词: MicroRNA 支气管哮喘 气道炎症 气道重塑 |
| DOI：10.3969/j.issn.1674-3806.2014.03.28 |
| 分类号:R 56 |
| 基金项目: |
|
| Role of miRNA and their abnormal express in pathogenesis and progression of bronchial asthma |
|
PENG Qiu-xiang, TAN Yi
|
|
Department of Pediatrics,the People′s Hospital of Hanshou County, Hunan 415900,China
|
| Abstract: |
| ［Abstract］ MicroRNA（miRNA）are a class of endogenous and small molecule noncoding single-stranded RNAs with highly conserved sequences among different specis,about 18～22 nucleotides(nt),and have tissue specificity and time sequences specificity. miRNA can regulate the translation or expression of target miRNA at the post-transcriptional level and play important roles in the biological precesses of cell growth, cell proliferation, metabolism, apoptosis and so on.A number of studies have demeonstrated that miRNA have a close relationship with pathogenesis and development of bronchial asthma(asthma)which had been found to express abnormally in asthma for some miRNA such as let-7 family, miR-125 family, miR-26 family, miR-155, miR-21, miR-133a, miR-26a, miR-221, etc. Here is to discuss the role of miRNA in foundation of pathology and physiology of asthma and the pathogenesis mainly characterized by persistent airway inflammation，airway hyperresponsiveness and airway remodeling. |
| Key words: MicroRNA(miRNA) Bronchial asthma Airway inflammation Airway remodeling |
