妊娠中期危险因素与子痫前期的相关性分析

马银瑶; 严思萍; 田　矛; 邬　华; 梁旭霞

引用本文:	马银瑶，严思萍，田　矛，邬　华，梁旭霞.妊娠中期危险因素与子痫前期的相关性分析[J].中国临床新医学,2015,8(1):13-16.

【打印本页】【下载PDF全文】【查看/发表评论】【EndNote】【RefMan】【BibTex】

←前一篇|后一篇→

过刊浏览高级检索

本文已被：浏览 1162次下载 1000次	码上扫一扫！
分享到：微信更多字体:加大+\|默认\|缩小-
妊娠中期危险因素与子痫前期的相关性分析
马银瑶，严思萍，田　矛，邬　华，梁旭霞
530021　南宁，广西壮族自治区人民医院产科

摘要:

［摘要］　目的　探讨妊娠中期主要危险因素与子痫前期（PE）的关系。方法　选取320例孕中期产妇，记录年龄、体重增加值、平均动脉压等一般体检资料，并采用全自动生化仪测定各孕妇血清总钙［TCa］_o含量及离子钙［Ca²⁺］_o含量；酶联免疫法测定CD4⁺CD25⁺Treg免疫抑制功能，随访至分娩，按妊娠期间孕妇是否发生PE分为PE组及正常对照组，观察各指标与PE发病的关系。结果　（1）随访结果：320例孕产妇妊娠期内有27例发展为PE，发生率约为8.44%，其中轻度21例，重度6例，其余293例为正常分娩。（2）子痫前期组与正常对照组比较，平均动脉压显著增高，而血清［TCa］_o、血清［Ca²⁺］_o及Treg抑制率显著降低，差异具有统计学意义（P<0.05）。两组年龄、体重增加值差异无统计学意义（P>0.05）；重度子痫前期组血清［Ca²⁺］_o含量低于轻度子痫前期组，差异具有统计学意义（P<0.05）。（3）血清钙水平与Treg抑制率的相关性分析表明，血清［TCa］_o、血清［Ca²⁺］_o与CD4⁺CD25⁺Treg抑制率的皮尔森（Pearson）系数分别为r₁=0.031，P=0.585；r₂=0.129，P=0.021，提示血清［TCa］_o水平与Treg抑制率无相关性，血清［Ca²⁺］_o水平与Treg抑制率则存在着正相关关系。结论　妊娠中期平均动脉压升高及血清［TCa］_o、［Ca²⁺］_o不足、CD4⁺CD25⁺Treg抑制功能下降是PE发病的危险因素，血清［Ca²⁺］_o与CD4⁺CD25⁺Treg抑制率具有密切的正相关关系。

关键词: 子痫前期危险因素钙 CD4⁺CD25⁺调节性T细胞

DOI：10.3969/j.issn.1674-3806.2015.01.05

分类号:R 714.24⁺5

基金项目:广西自然科学青年基金课题（编号：2014GXNSFBA118176）；广西卫生厅科研课题（编号：Z2013350）

Correlation analysis between risk factors in second trimester pregnant women and preeclampsia

MA Yin-yao, YAN Si-ping, TIAN Mao, et al.

Department of Obstetrics, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China

Abstract:

［Abstract］　Objective　To explore the correlation between main risk factors in second trimester pregnant women and preeclampsia(PE).Methods　Three hundred and twenty pregnant women were included in the study, and their general physical examination data were recorded,such as age,weight gain,mean arterial blood pressure etc.Automatic biochemistry analyzer was used to determinate the levels of serum total calcium(［TCa］_o) and ionized calcium(［Ca²⁺］_o). The suppression function of CD4⁺CD25⁺Tregs was detected by enzyme-linked immunosorbent assay.The pregnant women were followed up until delivery, and were divided into PE group and control group(pregnant women without PE). The correlation of these indexes and PE was observed.Results　(1)Follow-up outcomes: among 320 pregnant women,27 cases developed PE(PE group),the incidence was about 8.44%, including 21 cases of mild PE, 6 cases of severe; 293 cases had normal delivery(normal group).(2)Compared with the normal group, mean arterial blood pressure was higher in the PE group; serum ［TCa］_o, serum ［Ca²⁺］_o and Treg inhibition rate were lower(P<0.05).There were no significant differences in age, weight gain(P>0.05).In severe PE group serum ［Ca²⁺］_o was lower than that in mild PE group, the difference was statistically significant(P<0.05). (3)Correlation between levels of serum［TCa］_o,serum［Ca²⁺］_o and CD4⁺CD25⁺Treg inhibition rate: the Pearson coefficients of serum［TCa］_o,serum［Ca²⁺］_o and CD4⁺CD25⁺Treg inhibition rate were r₁=0.031,P=0.585;r₂=0.129,P=0.021, respectively, indicating that there was no correlation between TCa levels in serum and Treg inhibition rate but that there was a positive correlation between serum［Ca²⁺］_o and Treg inhibition rate.Conclusion　Insufficient serum［TCa］_o,serum［Ca²⁺］_o, deficient CD4⁺CD25⁺Treg inhibition function and increased mean arterial pressure are independent risk factors of PE in the second trimester pregnant women. There was a close positive correlation between serum ［Ca²⁺］_o and CD4⁺CD25⁺Treg inhibition rate.

Key words: Preeclampsia Risk factors Calcium CD4⁺CD25⁺regulatory T cells