| 摘要: |
| ［摘要］ 目的 探索CD4+CD25+调节性T细胞(Treg)在白细胞(WBC)降低性肺炎(LP)中的表达及临床意义。方法 对40例LP患者进行血常规及Treg检测和痰培养，将Treg与WBC及病原体类型进行相关性分析。结果 LP组患者Treg、WBC及单核细胞(MON)均明显降低(P<0.05)。痰培养显示肺炎支原体(MP)占26例并均予阿奇霉素治疗，发现第3天Treg频率显著高于第1天(P=0.028)。Treg与WBC及MON比例均呈正相关性(P<0.05)，但与中性粒细胞及淋巴细胞均呈负相关性(P<0.05)；Treg与MP感染存在显著负相关性(P<0.05)。结论 Treg频率降低是LP的重要免疫表现，有助于支原体肺炎的早期诊断及疗效判断。 |
| 关键词: 白细胞降低性肺炎 CD4+CD25+ T细胞 发病机制 |
| DOI：10.3969/j.issn.1674-3806.2015.07.07 |
| 分类号:R 563.1 |
| 基金项目: |
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| Expression and significance of CD4+CD25+ regulatory T cells(Treg) in the pathogenesis for the pneumonia patients with leucopenia |
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LIN Yan-mei
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Department of Internal Medicine, Dalang Hospital, Guangdong 523770, China
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| Abstract: |
| ［Abstract］ Objective To explore the expression and significance of CD4+CD25+ regulatory T cells (Treg) for the patients with leucopenia pneumonia(LP).Methods Forty patients with LP were enrolled and their blood routine examination, Treg testing and sputum cultivation were done. The correlations between Treg, white blood cell(WBC) and pathogens were analyzed.Results Compared with the control group, Treg, WBC and monocytes(MON) decreased significantly(P<0.05).Sputum cultivation showed that there were 26 patients suffering from mycoplasma(MP) infection and they were all treated with azithromycin. The frequencies of Treg on the 3rd day of the MP patients were significantly higher than those on the 1st day during azithromycin treatment(P=0.028). Correlation analysis showed that Treg was positively related to WBC and MON(P<0.05), whereas Treg was negatively related to neutrophil granulocyte and lymphocyte, as well as the MP(P<0.05).Conclusion Decreasing of Treg is one of the important immunological features for patients with LP, which can help the early diagnosis and curative effect evaluation for the MP. |
| Key words: Leucopenia pneumonia CD4+CD25+ regulatory T cells Pathogenesis |
